Mero-25Homo sapiens (Human)Cancer cell line
Also known as: MERO25
🤖 AI SummaryBased on 4 publications
Quick Overview
Human malignant mesothelioma cell line derived from pleural effusion, used in cancer research.
Detailed Summary
Mero-25 is a human malignant mesothelioma cell line established from pleural effusion material. It exhibits characteristics of malignant mesothelioma, including abnormal karyotypes and specific intermediate filament expression. The cell line has been used in studies investigating the cytoskeletal organization, motility, and invasive properties of mesothelioma cells. Research has shown that Mero-25 displays distinct actin filament organization and migratory behavior, contributing to the understanding of mesothelioma progression. Additionally, the cell line has been utilized to study the Hippo signaling pathway and its role in tumor development. Mero-25 is valuable for in vitro studies on mesothelioma biology and therapeutic target identification.
Research Applications
Cytoskeletal dynamics and cell motilityHippo signaling pathway analysisInvasive properties of mesothelioma cellsIntermediate filament expression studies
Key Characteristics
Abnormal karyotypeExpression of vimentin and cytokeratinsDistinct actin filament organizationMigratory and invasive capabilities
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2591 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung, pleura[UBERON:UBERON_0000977] |
Donor Information
| Age | 60 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Biphasic Type |
| OncoTree Code | PLBMESO |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001556_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,12
D13S317
12
D16S539
11,12
D18S51
18
D21S11
30,31
D3S1358
15
D5S818
11,12
D7S820
9
D8S1179
13
FGA
21
Penta D
9,13
Penta E
7,16
TH01
8
TPOX
9
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells.
Keller M., Reis K., Hjerpe A., Dobra K., Aspenstrom P.
Cancers (Basel) 13:685.1-685.20(2021).
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).
Characterization of three human malignant mesothelioma cell lines.";
van der Kwast T.H., Delahaye M., Schaart G., Ramaekers F.C.S.
Cancer Genet. Cytogenet. 42:115-128(1989).