Mero-41Homo sapiens (Human)Cancer cell line
Also known as: MERO41
🤖 AI SummaryBased on 3 publications
Quick Overview
Malignant mesothelioma cell line for cancer research.
Detailed Summary
Mero-41 is a human malignant mesothelioma cell line established from pleural effusion or autopsy material. It exhibits a hyperdiploid karyotype and expresses intermediate filament proteins such as vimentin and cytokeratins 7, 8, 18, and 19. The cell line shows resistance to growth inhibition by epidermal growth factor (EGF) and hydrocortisone (HC), and it does not require these factors for proliferation. Cytogenetic analysis confirms its malignant mesothelioma origin, with marker chromosomes 1, 3, 9, and 22. Mero-41 is used in studies of mesothelioma biology, genetic alterations, and therapeutic targeting of the Hippo pathway.
Research Applications
Cytogenetic studiesIntermediate filament expression analysisHippo pathway researchTherapeutic target identification
Key Characteristics
Hyperdiploid karyotypeExpression of vimentin and cytokeratins 7, 8, 18, 19Resistance to EGF and HC growth inhibitionMarker chromosomes 1, 3, 9, 22
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2592 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 60 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001557_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,11
D13S317
13
D16S539
12
D18S51
14
D21S11
30,31.2
D3S1358
16
D5S818
13
D7S820
9
D8S1179
12,14
FGA
22
Penta D
9,11
Penta E
7,15
TH01
6,8
TPOX
8
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).
Characterization of three human malignant mesothelioma cell lines.";
van der Kwast T.H., Delahaye M., Schaart G., Ramaekers F.C.S.
Cancer Genet. Cytogenet. 42:115-128(1989).