Mero-48aHomo sapiens (Human)Cancer cell line
Also known as: MERO48A
🤖 AI SummaryBased on 2 publications
Quick Overview
Human malignant mesothelioma cell line for cancer research.
Detailed Summary
Mero-48a is a human malignant mesothelioma cell line established from pleural effusions and solid tumor material. It exhibits abnormal karyotypes and expresses epithelial membrane antigen (EMA), distinguishing it from normal mesothelial cells. The cell line shows variable doubling times and does not undergo senescence. It is used in studies related to mesothelioma biology, cytogenetics, and therapeutic development. Research indicates potential involvement of the Hippo signaling pathway in its pathogenesis, with mutations in genes like NF2 and LATS2 observed in related cell lines.
Research Applications
Cancer researchMesothelioma biologyCytogeneticsTherapeutic development
Key Characteristics
Abnormal karyotypesExpression of EMAVariable doubling timesNo senescence
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2593 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Biphasic Type |
| OncoTree Code | PLBMESO |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001558_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
11
D16S539
9,11
D18S51
12
D21S11
27,32.2
D3S1358
14,16
D5S818
11,12
D7S820
9,10
D8S1179
13,14
FGA
19
Penta D
14
Penta E
16
TH01
9.3
TPOX
8
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).