Mero-82Homo sapiens (Human)Cancer cell line
Also known as: MERO82
🤖 AI SummaryBased on 2 publications
Quick Overview
Human malignant mesothelioma cell line for cancer research.
Detailed Summary
Mero-82 is a human malignant mesothelioma cell line established from pleural effusions. It exhibits characteristics typical of malignant mesothelioma, including spindle-shaped or epithelial morphology, multinucleate cells, and frequent mitotic figures. The cell line shows variable doubling times, with some lines doubling every 24 hours. Cytogenetic analysis reveals abnormal karyotypes, and the cell line expresses epithelial membrane antigen (EMA), distinguishing it from normal mesothelial cells. Mero-82 is used in research to study the biology of malignant mesothelioma, including genetic alterations, tumorigenicity, and potential therapeutic targets.
Research Applications
Cancer researchMalignant mesothelioma studiesGenetic and cytogenetic analysisTumorigenicity studies
Key Characteristics
Spindle-shaped or epithelial morphologyAbnormal karyotypesExpression of epithelial membrane antigen (EMA)Variable doubling times
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2594 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Unknown |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001559_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Leu194Arg (c.581T>G) | Unspecified | - | PubMed=20575032 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,13
D13S317
12
D16S539
12
D18S51
13
D21S11
30
D3S1358
18
D5S818
11,12
D7S820
10
D8S1179
13
FGA
24
Penta D
13
Penta E
11
TH01
9.3
TPOX
8
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).