Mero-95Homo sapiens (Human)Cancer cell line
Also known as: MERO95
🤖 AI SummaryBased on 2 publications
Quick Overview
Human malignant mesothelioma cell line for cancer research.
Detailed Summary
Mero-95 is a human malignant mesothelioma cell line established from pleural effusions and solid tumor material. It exhibits characteristics of malignant mesothelioma cells, including spindle-shaped or epithelial morphology, multinucleate cells, and frequent mitotic figures. The cell line shows variable doubling times, with some lines doubling every 24 hours and others every 48 hours. Cytogenetic analysis reveals abnormal karyotypes, with specific markers consistent with the patient's tumor. Mero-95 does not require EGF and/or HC for growth after establishment. It is used in research to study the properties of malignant mesothelioma cells and to develop diagnostic methods.
Research Applications
Cancer researchMesothelioma studiesCytogenetic analysisCell line development
Key Characteristics
Malignant mesothelioma cellsAbnormal karyotypesVariable doubling timesSpindle-shaped or epithelial morphology
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2597 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001562_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
11,12
D16S539
11
D18S51
14,17
D21S11
28,30
D3S1358
14,15
D5S818
11,14
D7S820
7,9
D8S1179
11,15
FGA
21,23
Penta D
12,13
Penta E
11,12
TH01
6
TPOX
8,12
vWA
18,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).