MM127Homo sapiens (Human)Cancer cell line

Also known as: MM-127

🤖 AI SummaryBased on 8 publications

Quick Overview

Human melanoma cell line with unique characteristics

Detailed Summary

MM127 is a human melanoma cell line derived from metastatic melanoma. It is notable for its lack of expression of standard melanoma-associated markers such as S100, HMB-45, and Melan-A, making it challenging to identify using conventional methods. This cell line has been used in various studies focusing on BRAF mutations and gene expression profiles. Research indicates that MM127 exhibits distinct genetic alterations, including BRAF mutations, which are common in melanoma. The cell line is also involved in studies related to the Wnt/β-catenin pathway and has been used to investigate the role of specific genes in melanoma progression. Despite its unique properties, MM127 is widely utilized in melanoma research due to its availability and relevance to metastatic disease.

Research Applications

Melanoma researchBRAF mutation studiesGene expression profilingWnt/β-catenin pathway analysis

Key Characteristics

Lacks standard melanoma markersBRAF mutationsMetastatic origin

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2601
Species	Homo sapiens (Human)
Tissue Source	Hypodermis[UBERON:UBERON_0002072]

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Amelanotic melanoma
Lineage	Skin
Subtype	Melanoma
OncoTree Code	MEL

DepMap Information

Source Type	Sigma-Aldrich
Source ID	ACH-001563_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	NRAS	p.Gly13Arg (c.37G>C)	Unspecified	-	PubMed=23455323
MutationSimple	CTNNB1	p.Ser45del (c.133_135delTCT)	Homozygous	-	PubMed=33379206
Gene deletion	CDKN2A	-	Homozygous	Possible	PubMed=26870271

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,11

D13S317

12,13

D16S539

10,13

D18S51

15,20

D19S433

13,14

D21S11

D2S1338

19,20

D3S1358

15,17

D5S818

11,12

D7S820

10,11

D8S1179

14,15

FGA

19,20

Penta D

Penta E

5,10

TH01

8,9

TPOX

11,12

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Standard melanoma-associated markers do not identify the MM127 metastatic melanoma cell line.

Haridas P., McGovern J.A., Kashyap A.S., McElwain D.L.S., Simpson M.J.

Sci. Rep. 6:24569-24569(2016).

DOI PubMed PMC

A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.

Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.

Mol. Cancer Ther. 11:888-897(2012).

DOI PubMed

Confirmation of a BRAF mutation-associated gene expression signature in melanoma.

Johansson P., Pavey S., Hayward N.K.

Pigment Cell Res. 20:216-221(2007).

DOI PubMed

Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.

Stark M.S., Hayward N.K.

Cancer Res. 67:2632-2642(2007).

DOI PubMed

Microarray expression profiling in melanoma reveals a BRAF mutation signature.

Meltzer P.S., Ringner M., Hayward N.K.

Oncogene 23:4060-4067(2004).

DOI PubMed

Mutations in exon 3 of the beta-catenin gene are rare in melanoma cell lines.

Pollock P.M., Hayward N.K.

Melanoma Res. 12:183-186(2002).

DOI PubMed

p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.

Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.

Br. J. Cancer 79:921-926(1999).

DOI PubMed PMC

CDKN2A/p16 is inactivated in most melanoma cell lines.";

Gabrielli B.G., Parsons P.G., Hayward N.K.

Cancer Res. 57:4868-4875(1997).

PubMed

Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.

Chenevix-Trench G., Martin N.G., Ellem K.A.O.

Oncogene 5:1187-1193(1990).

PubMed

The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.

Goss P.D., Parsons P.G.

Cancer Res. 37:152-156(1977).

PubMed

Human malignant melanoma cell lines.";

Pope J.H., Morrison L.E., Moss D.J., Parsons P.G., Dunne R.M.

Pathology 11:191-195(1979).

DOI PubMed

A cytogenetic study of eight human melanoma cell lines.";

Muir P.D., Gunz F.W.

Pathology 11:597-606(1979).

DOI PubMed