MM370Homo sapiens (Human)Cancer cell line
Also known as: MM 370
🤖 AI SummaryBased on 4 publications
Quick Overview
MM370 is a melanoma cell line with BRAF mutation and specific gene expression signature.
Detailed Summary
MM370 is a melanoma cell line derived from human melanoma tissue, characterized by a BRAF mutation. It has been used in studies to identify gene expression signatures associated with BRAF mutations. Research indicates that MM370 exhibits a distinct gene expression profile that can differentiate it from BRAF wild-type melanoma cell lines. This cell line is valuable for understanding the molecular mechanisms of melanoma and for developing targeted therapies. The BRAF mutation in MM370 contributes to the activation of the MAPK pathway, which is a key factor in melanoma progression. Additionally, MM370 has been involved in studies examining the relationship between sun exposure and p53 mutations, although specific details about p53 status in MM370 are not provided in the available data.
Research Applications
BRAF mutation analysisGene expression profilingMAPK pathway activation studies
Key Characteristics
BRAF mutationDistinct gene expression signatureInvolvement in melanoma research
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2605 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001566_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,12
D13S317
11,12
D16S539
8
D18S51
14,15
D19S433
12,13
D21S11
27,32
D2S1338
17
D3S1358
14,16
D5S818
11,12
D7S820
11,12
D8S1179
13,14
FGA
21,24
TH01
9.3
TPOX
8,9
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Johansson P., Pavey S., Hayward N.K.
Pigment Cell Res. 20:216-221(2007).
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Stark M.S., Hayward N.K.
Cancer Res. 67:2632-2642(2007).
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Meltzer P.S., Ringner M., Hayward N.K.
Oncogene 23:4060-4067(2004).
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.
Br. J. Cancer 79:921-926(1999).
CDKN2A/p16 is inactivated in most melanoma cell lines.";
Gabrielli B.G., Parsons P.G., Hayward N.K.
Cancer Res. 57:4868-4875(1997).
Cross-sensitivity of methylating agents, hydroxyurea, and methotrexate in human tumor cells of the Mer- phenotype.
Maynard K., Parsons P.G.
Cancer Res. 46:5009-5013(1986).