MM383Homo sapiens (Human)Cancer cell line

Also known as: MM 383

🤖 AI SummaryBased on 3 publications

Quick Overview

Human melanoma cell line with BRAF mutation signature

Detailed Summary

MM383 is a human melanoma cell line with a known BRAF mutation signature. Research has shown that this cell line exhibits distinct gene expression profiles associated with BRAF mutations, which can be used to predict mutation status in melanoma samples. The cell line has been utilized in studies involving microarray gene expression profiling and support vector machine (SVM) analysis to identify BRAF mutation signatures. These findings contribute to understanding the molecular mechanisms underlying melanoma development and may aid in the identification of therapeutic targets.

Research Applications

BRAF mutation detectionGene expression profilingSupport vector machine (SVM) analysis

Key Characteristics

BRAF mutation signatureDistinct gene expression profiles
Generated on 6/19/2025

Basic Information

Database IDCVCL_2606
SpeciesHomo sapiens (Human)
Tissue SourceLymph node[UBERON:UBERON_0000029]

Donor Information

Age CategoryUnknown
SexMale

Disease Information

DiseaseMelanoma
LineageSkin
SubtypeMelanoma
OncoTree CodeMEL

DepMap Information

Source TypeSigma-Aldrich
Source IDACH-001567_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleBRAFp.Val600Glu (c.1799T>A)Unspecified-PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
11
D13S317
8,12
D16S539
9,12
D18S51
23
D19S433
15.2
D21S11
29,31
D2S1338
16,19
D3S1358
17
D5S818
11,12
D7S820
10,11
D8S1179
13,14
FGA
24
Penta D
9,14
Penta E
11
TH01
6
TPOX
8,11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Confirmation of a BRAF mutation-associated gene expression signature in melanoma.

Johansson P., Pavey S., Hayward N.K.

Pigment Cell Res. 20:216-221(2007).

Microarray expression profiling in melanoma reveals a BRAF mutation signature.

Meltzer P.S., Ringner M., Hayward N.K.

Oncogene 23:4060-4067(2004).

p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.

Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.

Br. J. Cancer 79:921-926(1999).

CDKN2A/p16 is inactivated in most melanoma cell lines.";

Gabrielli B.G., Parsons P.G., Hayward N.K.

Cancer Res. 57:4868-4875(1997).

Cross-sensitivity of methylating agents, hydroxyurea, and methotrexate in human tumor cells of the Mer- phenotype.

Maynard K., Parsons P.G.

Cancer Res. 46:5009-5013(1986).