MM386Homo sapiens (Human)Cancer cell line
Also known as: MM 386
🤖 AI SummaryBased on 4 publications
Quick Overview
MM386 is a melanoma cell line with BRAF mutation and potential for research in melanoma genetics.
Detailed Summary
MM386 is a melanoma cell line derived from human tissue, characterized by a BRAF mutation. It is used in research to study the genetic alterations associated with melanoma, particularly focusing on the BRAF mutation signature. The cell line has been analyzed for its gene expression profiles and has shown specific patterns linked to BRAF mutations, which are critical in the activation of the MAPK pathway. This cell line is valuable for understanding the molecular mechanisms of melanoma and for developing targeted therapies. Additionally, MM386 has been part of studies examining the relationship between sun exposure and p53 mutations, although specific details about p53 status in this cell line are not provided in the available data.
Research Applications
BRAF mutation analysisGene expression profilingMelanoma genetics research
Key Characteristics
BRAF mutationGene expression signature associated with BRAF mutation
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2607 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001568_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg290His (c.869G>A) | Unspecified | - | PubMed=10070891 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
| Gene deletion | PTEN | - | Hemizygous | - | Wistar |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12,14
D13S317
8,12
D16S539
11
D18S51
12
D19S433
14
D21S11
30,32
D2S1338
26
D3S1358
15
D5S818
11,13
D7S820
8,9
D8S1179
13
FGA
20,22
Penta D
9,12
Penta E
11,12
TH01
6,8
TPOX
8,9
vWA
16,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Johansson P., Pavey S., Hayward N.K.
Pigment Cell Res. 20:216-221(2007).
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Stark M.S., Hayward N.K.
Cancer Res. 67:2632-2642(2007).
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Meltzer P.S., Ringner M., Hayward N.K.
Oncogene 23:4060-4067(2004).
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.
Br. J. Cancer 79:921-926(1999).
CDKN2A/p16 is inactivated in most melanoma cell lines.";
Gabrielli B.G., Parsons P.G., Hayward N.K.
Cancer Res. 57:4868-4875(1997).