MM415Homo sapiens (Human)Cancer cell line
Also known as: MM 415
🤖 AI SummaryBased on 4 publications
Quick Overview
MM415 is a melanoma cell line with BRAF mutations, used in cancer research.
Detailed Summary
MM415 is a melanoma cell line derived from human tissue, characterized by BRAF mutations. It is utilized in research to study the molecular mechanisms of melanoma, particularly focusing on BRAF mutation signatures and their implications in cancer progression. The cell line has been analyzed for gene expression profiles and has shown specific patterns associated with BRAF mutations, contributing to the understanding of melanoma biology and potential therapeutic targets. Research involving MM415 has highlighted the importance of BRAF mutations in melanoma development and has been instrumental in identifying gene expression signatures linked to these mutations.
Research Applications
BRAF mutation analysisGene expression profilingMelanoma research
Key Characteristics
BRAF mutationGene expression signature
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2608 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001569_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NRAS | p.Gln61Leu (c.182A>T) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
9,13
D16S539
11
D18S51
14,20
D19S433
14,15.2
D21S11
27,28
D2S1338
17,19
D3S1358
14,15
D5S818
11
D7S820
9,11
D8S1179
14
FGA
23,25
Penta D
11,13
Penta E
10,12
TH01
6,9
TPOX
8,11
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Johansson P., Pavey S., Hayward N.K.
Pigment Cell Res. 20:216-221(2007).
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Stark M.S., Hayward N.K.
Cancer Res. 67:2632-2642(2007).
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Meltzer P.S., Ringner M., Hayward N.K.
Oncogene 23:4060-4067(2004).
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.
Br. J. Cancer 79:921-926(1999).
CDKN2A/p16 is inactivated in most melanoma cell lines.";
Gabrielli B.G., Parsons P.G., Hayward N.K.
Cancer Res. 57:4868-4875(1997).