MM426Homo sapiens (Human)Cancer cell line
Also known as: MM 426
🤖 AI SummaryBased on 3 publications
Quick Overview
Human melanoma cell line with BRAF mutation
Detailed Summary
MM426 is a human melanoma cell line with a known BRAF mutation. It is used in research to study the genetic and molecular mechanisms of melanoma, particularly focusing on BRAF mutation-associated gene expression profiles. The cell line has been analyzed for its mutation status, including BRAF and NRAS, and has been part of studies examining the impact of BRAF mutations on gene expression and potential therapeutic targets. MM426 is also involved in studies related to loss of heterozygosity (LOH) and copy number changes, contributing to the understanding of melanoma genetics.
Research Applications
BRAF mutation analysisGene expression profilingLoss of heterozygosity (LOH) studiesCopy number variation analysis
Key Characteristics
BRAF mutation (V599E)NRAS wild-typeCDKN2A wild-typePTEN wild-type
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2609 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001570_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | CDKN2A | p.Glu88Ter (c.262G>T) | Heterozygous | - | Unknown |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
8,11
D16S539
11,13
D18S51
15,18
D19S433
14,15
D21S11
28,30
D2S1338
21
D3S1358
17
D5S818
9,12
D7S820
8,11
D8S1179
10,16
FGA
23
Penta D
9,11
Penta E
11,14
TH01
8,9
TPOX
8
vWA
15
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Johansson P., Pavey S., Hayward N.K.
Pigment Cell Res. 20:216-221(2007).
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Stark M.S., Hayward N.K.
Cancer Res. 67:2632-2642(2007).
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Meltzer P.S., Ringner M., Hayward N.K.
Oncogene 23:4060-4067(2004).
CDKN2A/p16 is inactivated in most melanoma cell lines.";
Gabrielli B.G., Parsons P.G., Hayward N.K.
Cancer Res. 57:4868-4875(1997).