MM485Homo sapiens (Human)Cancer cell line

Also known as: MM 485

🤖 AI SummaryBased on 5 publications

Quick Overview

MM485 is a melanoma cell line with BRAF mutation and potential for research in melanoma therapies.

Detailed Summary

MM485 is a melanoma cell line derived from human tissue, characterized by a BRAF mutation. It has been used in studies to identify gene expression signatures associated with BRAF mutations, which are critical in melanoma development. Research on MM485 has contributed to understanding the molecular mechanisms of melanoma and the development of targeted therapies. The cell line is also involved in studies examining the relationship between UV exposure and p53 mutations, although no significant correlation was found in this specific cell line. MM485 is valuable for investigating the genetic and molecular changes in melanoma, particularly in the context of BRAF and p53 mutations, and their implications for treatment strategies.

Research Applications

BRAF mutation analysisGene expression profilingMelanoma therapy developmentp53 mutation studies

Key Characteristics

BRAF mutationPotential for targeted therapy research

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2610
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Amelanotic melanoma
Lineage	Skin
Subtype	Melanoma
OncoTree Code	MEL

DepMap Information

Source Type	CellBank Australia
Source ID	ACH-001973_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	NRAS	p.Gln61Arg (c.182A>G)	Unspecified	-	PubMed=26214590
MutationSimple	CDKN2A	p.Trp100Ter	Homozygous	-	Unknown, PubMed=17363583, PubMed=9354451

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

11,13

D16S539

D18S51

13,17

D19S433

12,14

D21S11

D2S1338

17,20

D3S1358

D5S818

11,12

D7S820

D8S1179

11,13

FGA

21,23

Penta D

10,12

Penta E

10,15

TH01

TPOX

9,10

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Confirmation of a BRAF mutation-associated gene expression signature in melanoma.

Johansson P., Pavey S., Hayward N.K.

Pigment Cell Res. 20:216-221(2007).

DOI PubMed

Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.

Stark M.S., Hayward N.K.

Cancer Res. 67:2632-2642(2007).

DOI PubMed

Microarray expression profiling in melanoma reveals a BRAF mutation signature.

Meltzer P.S., Ringner M., Hayward N.K.

Oncogene 23:4060-4067(2004).

DOI PubMed

p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.

Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.

Br. J. Cancer 79:921-926(1999).

DOI PubMed PMC

Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells.

Coupar B., Qiu L., Parsons P.G., Moss D.J., Khanna R.

Int. J. Cancer 75:590-595(1998).

DOI PubMed

CDKN2A/p16 is inactivated in most melanoma cell lines.";

Gabrielli B.G., Parsons P.G., Hayward N.K.

Cancer Res. 57:4868-4875(1997).

PubMed

Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.

Toso R.J., Herlyn M., Bennett D.C.

Cancer Res. 55:2528-2532(1995).

PubMed

Monoclonal antibody against human tyrosinase and reactive with melanotic and amelanotic melanoma cells.

McEwan M., Parsons P.G., Moss D.J.

J. Invest. Dermatol. 90:515-519(1988).

DOI PubMed

Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.

Chenevix-Trench G., Martin N.G., Ellem K.A.O.

Oncogene 5:1187-1193(1990).

PubMed