MM576Homo sapiens (Human)Cancer cell line
Also known as: MM 576
🤖 AI SummaryBased on 2 publications
Quick Overview
Human melanoma cell line with BRAF mutation and p16INK4a alterations.
Detailed Summary
MM576 is a human melanoma cell line characterized by specific genetic alterations, including BRAF mutations and p16INK4a inactivation. These features make it a valuable model for studying melanoma pathogenesis and therapeutic targets. Research on MM576 has contributed to understanding the role of BRAF mutations in gene expression signatures and the disruption of the p16INK4a-pRb pathway in melanoma progression. The cell line has been utilized in studies examining the molecular mechanisms underlying melanoma development and potential treatment strategies.
Research Applications
BRAF mutation analysisp16INK4a inactivation studiesMelanoma pathogenesisGene expression profilingTherapeutic target identification
Key Characteristics
BRAF mutationp16INK4a inactivationDisruption of p16INK4a-pRb pathway
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2611 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Unknown |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | CellBank Australia |
|---|---|
| Source ID | ACH-001975_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
8,9
D16S539
13
D18S51
16
D19S433
15,17
D21S11
29,30
D2S1338
20
D3S1358
18
D5S818
11
D7S820
12
D8S1179
14,15
FGA
20
TH01
9.3
TPOX
8,11
vWA
15,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Johansson P., Pavey S., Hayward N.K.
Pigment Cell Res. 20:216-221(2007).
Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells.
Mann G.J.
Melanoma Res. 9:10-19(1999).
Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells.
Coupar B., Qiu L., Parsons P.G., Moss D.J., Khanna R.
Int. J. Cancer 75:590-595(1998).
CDKN2A/p16 is inactivated in most melanoma cell lines.";
Gabrielli B.G., Parsons P.G., Hayward N.K.
Cancer Res. 57:4868-4875(1997).