MM603Homo sapiens (Human)Cancer cell line

MM603 is a melanoma cell line derived from human tissue, characterized by a BRAF mutation (V599E). It is utilized in research to study the molecular mechanisms of melanoma, particularly focusing on BRAF mutation-associated gene expression signatures. The cell line has been analyzed for loss of heterozygosity (LOH) and copy number changes, revealing frequent alterations on chromosome arms 9p, 10p, 10q, 9q, 6q, 11q, and 17p. MM603 has been used in studies involving microarray gene expression profiling and support vector machine (SVM) analysis to identify gene expression patterns linked to BRAF mutations. It is also part of panels used to validate the effectiveness of classifiers for predicting BRAF mutation status in melanoma samples.