MOR/CPRHomo sapiens (Human)Cancer cell line
Also known as: MORCPR, MOR-CPR
🤖 AI SummaryBased on 2 publications
Quick Overview
Human cell line with potential applications in cancer research and drug sensitivity studies.
Detailed Summary
The MOR/CPR cell line, identified by the ID CVCL_2620, is a human cell line with limited available information regarding its tissue origin, disease association, and specific cell type. Despite this, it is part of the Cancer Cell Line Encyclopedia (CCLE), a comprehensive resource that includes genomic and pharmacological data for a wide range of cancer cell lines. The CCLE provides insights into drug sensitivity and resistance, which can be leveraged for predictive modeling in cancer therapy. Research involving the CCLE has highlighted the importance of genomic diversity in understanding cancer biology and developing targeted treatments. While specific details about MOR/CPR are not provided in the available data, its inclusion in the CCLE suggests it may be used in studies related to drug response, genetic predictors of sensitivity, and the development of personalized cancer therapies.
Research Applications
Cancer researchDrug sensitivity studiesGenomic diversity analysisPredictive modeling in cancer therapy
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Potential for drug response studiesGenomic data available for analysis
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2620 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Unknown |
Disease Information
| Disease | Lung adenocarcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Adenocarcinoma |
| OncoTree Code | LUAD |
DepMap Information
| Source Type | ECACC |
|---|---|
| Source ID | ACH-000851_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Pro152Argfs*18 (c.455delC) | Heterozygous | - | from parent cell line OVK18 |
| MutationSimple | KRAS | p.Gly13Cys (c.37G>T) | Heterozygous | - | Unknown, Unknown, PubMed=28273451, PubMed=25230021, PubMed=24224046, PubMed=22705003 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
12
D16S539
9
D5S818
12
D7S820
9,12
TH01
7
TPOX
11
vWA
15
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Sensitivity to novel platinum compounds of panels of human lung cancer cell lines with acquired and inherent resistance to cisplatin.
Twentyman P.R., Wright K.A., Mistry P., Kelland L.R., Murrer B.A.
Cancer Res. 52:5674-5680(1992).