NO36Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 3 publications
Quick Overview
Human malignant mesothelioma cell line for cancer research.
Detailed Summary
The NO36 cell line is a human malignant mesothelioma cell line derived from pleural effusions. It is used in research to study the genetic and molecular mechanisms of mesothelioma, particularly focusing on the Hippo signaling pathway and BAP1 mutations. NO36 exhibits characteristics such as loss of contact inhibition and abnormal karyotypes, which are common in mesothelioma cells. Research on NO36 has contributed to understanding the role of tumor suppressor genes and their mutations in the progression of mesothelioma.
Research Applications
Cancer researchGenetic studiesMolecular mechanisms of mesotheliomaHippo signaling pathwayBAP1 mutations
Key Characteristics
Loss of contact inhibitionAbnormal karyotypesMalignant mesothelioma
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2658 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age Category | Adult |
|---|---|
| Sex | Male |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | CellBank Australia |
|---|---|
| Source ID | ACH-001977_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BAP1 | p.Phe118Leufs*69 (c.354delC) | Heterozygous | - | PubMed=21642991 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,12
D13S317
8
D16S539
11,13
D18S51
21,22
D19S433
15,16
D21S11
28,29
D2S1338
25
D3S1358
15,16
D5S818
12,13
D7S820
11
D8S1179
12
FGA
22
TH01
6,7
TPOX
8,11
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.
Nat. Genet. 43:668-672(2011).