OE21Homo sapiens (Human)Cancer cell line

Also known as: JROECL21, JROECL 21, OE-21

🤖 AI SummaryBased on 7 publications

Quick Overview

OE21 is a human esophageal carcinoma cell line used in cancer research.

Detailed Summary

OE21 is a human esophageal carcinoma cell line derived from an adenocarcinoma of the esophagus. It is widely used in research to study the molecular mechanisms of cancer progression and drug response. The cell line has been characterized for its genetic and phenotypic properties, including its ability to form tumors in vivo and its response to various therapeutic agents. OE21 is part of a collection of cell lines that provide insights into the biology of esophageal cancer and its treatment.

Research Applications

Cancer biologyDrug screeningGenomic profiling

Key Characteristics

Tumorigenic in vivoResponse to therapeutic agentsGenetic stability
Generated on 6/19/2025

Basic Information

Database IDCVCL_2661
SpeciesHomo sapiens (Human)
Tissue SourceEsophagus[UBERON:UBERON_0001043]

Donor Information

Age74
Age CategoryAdult
SexMale

Disease Information

DiseaseSquamous cell carcinoma of the esophagus
LineageEsophagus/Stomach
SubtypeEsophageal Squamous Cell Carcinoma
OncoTree CodeESCC

DepMap Information

Source TypeHPACC
Source IDACH-000544_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11,12
D13S317
12
D16S539
12,13
D18S51
19
D19S433
15.2
D21S11
30,31
D2S1338
17,19
D3S1358
17
D5S818
12,13
D7S820
11,12
D8S1179
12
FGA
20
Penta D
11,12
Penta E
12
TH01
7,8
TPOX
8,11
vWA
15,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Hypermethylation of MAPK13 promoter in oesophageal squamous cell carcinoma is associated with loss of p38delta MAPK expression.

O'Callaghan C., Fanning L.J., Barry O.P.

Cancers (Basel) 7:2124-2133(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines.

Fitzgerald R.C.

Dis. Esophagus 19:10-14(2006).

Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization.

Rockett J.C., Larkin K., Darnton S.J., Morris A.G., Matthews H.R.

Br. J. Cancer 75:258-263(1997).