ONE58Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 3 publications
Quick Overview
Human malignant mesothelioma cell line for cancer research.
Detailed Summary
The ONE58 cell line is derived from human malignant mesothelioma, a highly aggressive cancer associated with asbestos exposure. This cell line is utilized in research to study the molecular mechanisms underlying mesothelioma progression and to evaluate potential therapeutic strategies. Key features include its epithelial morphology, expression of mesothelial markers such as EMA and cytokeratins, and the presence of chromosomal abnormalities typical of mesothelioma. The cell line has been used in studies investigating the role of the Hippo signaling pathway and BAP1 mutations in mesothelioma pathogenesis. Research applications include drug screening, gene expression analysis, and the development of targeted therapies.
Research Applications
Cancer researchMolecular mechanism studiesDrug screeningGene expression analysisTargeted therapy development
Key Characteristics
Epithelial morphologyExpression of mesothelial markers (EMA, cytokeratins)Chromosomal abnormalities
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2671 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 58 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | CellBank Australia |
|---|---|
| Source ID | ACH-001992_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Tyr205Cys (c.614A>G) | Heterozygous | - | from parent cell line Rh30 |
| MutationSimple | EP300 | p.Gln1993Ter (c.5797C>T) | Heterozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,12
D13S317
8,12
D16S539
12
D18S51
11,12
D19S433
12
D21S11
30,31.2
D2S1338
20,23
D3S1358
17
D5S818
12
D7S820
7,11
D8S1179
10,13
FGA
21
TH01
8,9
TPOX
8
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
A proteomic analysis of the malignant mesothelioma secretome using iTRAQ.
Creaney J., Dick I.M., Leon J.S., Robinson B.W.S.
Cancer Genomics Proteomics 14:103-117(2017).
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.
Nat. Genet. 43:668-672(2011).