OV7Homo sapiens (Human)Cancer cell line

Also known as: OV-7

🤖 AI SummaryBased on 5 publications

Quick Overview

OV7 is a human cancer cell line used in research.

Detailed Summary

OV7 is a human cancer cell line with unknown tissue and disease origins. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genetic and transcriptomic profiles. Research on OV7 focuses on understanding its role in cancer biology and drug sensitivity. The cell line is used to study various aspects of cancer, including gene expression, mutations, and response to therapeutic agents. Further research is needed to fully characterize its properties and applications.

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2675
Species	Homo sapiens (Human)
Tissue Source	Ovary[UBERON:UBERON_0000992]

Donor Information

Age	78
Age Category	Adult
Sex	Female

Disease Information

Disease	Ovarian carcinoma
Lineage	Ovary/Fallopian Tube
Subtype	Mixed Ovarian Carcinoma
OncoTree Code	MXOV

DepMap Information

Source Type	ECACC
Source ID	ACH-000688_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ile254Ser (c.761T>G)	Homozygous	-	Unknown, Unknown, PubMed=25230021
MutationSimple	RB1	p.Leu512Cysfs*10 (c.1534_1535delTT) (1533_1534del)	Heterozygous	-	Unknown, Unknown, PubMed=25230021
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

12,13

D13S317

8,11

D16S539

D18S51

12,14

D19S433

D21S11

30,31.2

D2S1338

20,24

D3S1358

D5S818

11,12

D7S820

9,11

D8S1179

10,14

FGA

Penta D

12,14

Penta E

10,12

TH01

7,9.3

TPOX

8,10

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

Helleman J.

PLoS ONE 9:E103988-E103988(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.

Barker P.J., Wright K.A., Twentyman P.R., Smith S.K.

J. Natl. Cancer Inst. 87:506-516(1995).

DOI PubMed