P4E6Homo sapiens (Human)Transformed cell line
🤖 AI SummaryBased on 1 publications
Quick Overview
P4E6 is a human prostate cancer cell line with distinct EMT and stem-like characteristics.
Detailed Summary
P4E6 is a human prostate cancer cell line derived from a primary tumour. It exhibits distinct epithelial-mesenchymal transition (EMT) characteristics, with some clones showing mesenchymal features such as vimentin expression and spindle-like morphology. The cell line has been used to study the relationship between EMT and cancer stem cells (CSCs) in prostate cancer. Research indicates that not all EMT-capable cells exhibit stem cell-like properties, and some clones demonstrate aggressive tumourigenic potential. P4E6 has been utilised in in vitro and in vivo assays to assess drug resistance, migration, invasion, and tumour formation, providing insights into the mechanisms of prostate cancer progression and metastasis.
Research Applications
Study of epithelial-mesenchymal transition (EMT) in prostate cancerInvestigation of cancer stem cell (CSC) propertiesAssessment of drug resistance and chemotherapeutic sensitivityAnalysis of cell migration and invasion mechanismsIn vivo tumourigenicity studies
Key Characteristics
Expression of vimentin and E-cadherin markersPresence of mesenchymal and epithelial populationsVariable EMT potential among clonesAggressive tumourigenic properties in some clonesDifferential drug resistance profiles
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2677 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Prostate[UBERON:UBERON_0002367] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Prostate carcinoma |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001627_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
11
D16S539
11
D18S51
16,18
D21S11
27,30.2
D3S1358
16,17
D5S818
12
D7S820
7,8
D8S1179
10,14
FGA
25
Penta D
9,12
Penta E
11
TH01
7,9.3
TPOX
8
vWA
17,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
A novel spontaneous model of epithelial-mesenchymal transition (EMT) using a primary prostate cancer derived cell line demonstrating distinct stem-like characteristics.
Reeder S., Pockley A.G., Rees R.C., Boocock D.J.
Sci. Rep. 7:40633-40633(2017).
Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction.
Maitland N.J.
In Vitro Cell. Dev. Biol. Anim. 42:273-280(2006).