PE/CA-PJ15Homo sapiens (Human)Cancer cell line

Also known as: PECAPJ15, PE CA PJ15, PE_CA-PJ15, PE/CA-PJ-15, PE/CA PJ15, PE-CA-PJ15

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line with unknown tissue and disease origins, used in cancer research.

Detailed Summary

PE/CA-PJ15 is a human cancer cell line with unknown tissue and disease origins. It is utilized in cancer research to study various aspects of tumor biology and drug sensitivity. The cell line's genetic and molecular characteristics are not fully characterized, and further research is needed to determine its specific applications and properties. Due to the lack of detailed information, its use in targeted therapies and biomarker discovery remains limited.

Research Applications

Cancer researchDrug sensitivity studies

Key Characteristics

Human originCancer cell line

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2678
Species	Homo sapiens (Human)
Tissue Source	Oral cavity, tongue[UBERON:UBERON_0001723]

Donor Information

Age	45
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the oral tongue
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	ECACC
Source ID	ACH-000619_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

8,10

D16S539

9,13

D18S51

D21S11

D3S1358

D5S818

11,13

D7S820

8,12

D8S1179

13,14

FGA

Penta D

Penta E

TH01

6,9.3

TPOX

8,11

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.

McDermott U., Garnett M.J., Cheong S.-C.

eLife 9:e57761.1-e57761.34(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Oral squamous cell carcinoma invasion is associated with a laminin-5 matrix re-organization but independent of basement membrane and hemidesmosome formation. Clues from an in vitro invasion model.

Berndt A., Hyckel P., Konneker A., Katenkamp D., Kosmehl H.

Invasion Metastasis 17:251-258(1997).

PubMed