PE/CA-PJ34 (clone C12)Homo sapiens (Human)Cancer cell line

Also known as: Plaepi 34, PJ34, PECAPJ34, PE CA PJ34, PE/CA-PJ-34, PE/CA-PJ34, PE-CA-PJ34-cl C12, PECAPJ34CLONEC12

🤖 AI SummaryBased on 6 publications

PE/CA-PJ34

Quick Overview

Human squamous cell carcinoma cell line with potential for metastasis.

Detailed Summary

PE/CA-PJ34 is a human squamous cell carcinoma cell line derived from head and neck cancer. It is used in research to study cancer progression, metastasis, and therapeutic responses. This cell line has been characterized in multiple studies, including those focusing on genetic mutations, viral integration, and protein expression profiles. Research involving PE/CA-PJ34 has contributed to understanding the molecular mechanisms underlying head and neck squamous cell carcinoma (HNSCC) and has been utilized in studies related to HPV infection, drug sensitivity, and metastatic potential. The cell line is part of larger panels of cell lines used for comprehensive cancer research and drug development.

Research Applications

Cancer progression studiesMetastasis researchTherapeutic response analysisGenetic mutation analysisViral integration studiesProtein expression profiling

Key Characteristics

Used in head and neck squamous cell carcinoma researchPart of larger cell line panels for comprehensive cancer studiesCharacterized in multiple studies for genetic and molecular profiles

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2679
Species	Homo sapiens (Human)
Tissue Source	Oral cavity[UBERON:UBERON_0000167]

Donor Information

Age	60
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the oral cavity
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	ECACC
Source ID	ACH-000606_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ala159Val (c.476C>T)	Homozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

9,13

D5S818

10,12

D7S820

9,10

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.

Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.

Oncotarget 8:86369-86383(2017).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.

Ito Y., Myers J.N., Oridate N.

J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.

Clin. Cancer Res. 17:7248-7264(2011).

DOI PubMed PMC

Oral squamous cell carcinoma invasion is associated with a laminin-5 matrix re-organization but independent of basement membrane and hemidesmosome formation. Clues from an in vitro invasion model.

Berndt A., Hyckel P., Konneker A., Katenkamp D., Kosmehl H.

Invasion Metastasis 17:251-258(1997).

PubMed

Web Resources

tcpaportal.org