RT112/84Homo sapiens (Human)Cancer cell line
Also known as: RT11284, RT-112/84, RT112-84
🤖 AI SummaryBased on 5 publications
Quick Overview
Human bladder cancer cell line with known chromosomal abnormalities.
Detailed Summary
The RT112/84 cell line is a human bladder carcinoma cell line derived from an epithelial tumor. It exhibits complex chromosomal abnormalities, including multiple rearrangements and marker chromosomes. Cytogenetic analysis revealed a mixture of two clones with nonrandom karyotic changes, such as deletions, isochromosomes, and translocations. These abnormalities include del(3)(p22), i(4)(p10), i(8)(q10), and der(11)(t3)(11). The cell line has been used in studies to investigate genetic alterations associated with bladder cancer progression and drug sensitivity. Research has also highlighted the importance of molecular profiling to understand tumor biology and improve translational research.
Research Applications
Cancer researchGenetic profilingDrug sensitivity studies
Key Characteristics
Chromosomal abnormalitiesMultiple rearrangementsMarker chromosomes
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2714 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Urinary bladder[UBERON:UBERON_0001255] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | ECACC |
|---|---|
| Source ID | ACH-001183_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Gln (c.743G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=20575032 |
| MutationSimple | TP53 | p.Ser183Ter (c.548C>G) | Homozygous | - | PubMed=30737244 |
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
| Gene fusion | FGFR3 | FGFR3-TACC3 | - | - | from parent cell line RT-4 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
13,14
D16S539
11,13
D5S818
10,13
D7S820
11,12
TH01
7
TPOX
8,11
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).