U-BLC1Homo sapiens (Human)Cancer cell line

U-BLC1 is a human bladder cancer cell line with documented TERT promoter mutations, making it a valuable tool for studying telomerase activation mechanisms in bladder cancer. The cell line has been used in research to detect TERT mutations in bladder tumours and urine samples, contributing to the understanding of bladder cancer genetics and potential biomarkers for non-invasive surveillance. U-BLC1 is part of a panel of cell lines analyzed for TERT mutations, highlighting its relevance in bladder cancer research. The cell line's characteristics include a high frequency of TERT promoter mutations, which are associated with both non-muscle-invasive and muscle-invasive bladder cancers. These mutations are linked to increased TERT promoter activity, suggesting a critical role in tumorigenesis. U-BLC1's utility extends to preclinical studies, where it can be used to evaluate therapeutic strategies targeting telomerase activation. The cell line's molecular profile supports its use in investigating the relationship between TERT mutations and cancer progression, offering insights into potential therapeutic targets.