UM-RC-3Homo sapiens (Human)Cancer cell line
Also known as: University of Michigan-Renal Carcinoma-3, UMRC3, UMRC-3
🤖 AI SummaryBased on 3 publications
Quick Overview
Human renal carcinoma cell line with VHL mutations and clear cell morphology.
Detailed Summary
UM-RC-3 is a human renal carcinoma cell line established from a clear cell tumor. It exhibits VHL gene mutations and loss of heterozygosity (LOH) in chromosome 3p, which are critical factors in renal carcinogenesis. This cell line has been used to study the molecular mechanisms of kidney cancer, particularly the role of VHL in tumor suppression. UM-RC-3 demonstrates characteristics of clear cell renal carcinoma, including cytoplasmic lipid accumulation and specific cell surface antigen reactivity. It has been utilized in research on tumor immunology, genetic alterations, and potential therapeutic targets.
Research Applications
VHL gene mutation analysisRenal carcinogenesis studiesTumor immunology researchCell surface antigen characterization
Key Characteristics
VHL mutationsChromosome 3p LOHClear cell morphologyCytoplasmic lipid accumulation
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2740 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Kidney[UBERON:UBERON_0002113] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Unknown |
Disease Information
| Disease | Clear cell renal carcinoma |
|---|---|
| Lineage | Kidney |
| Subtype | Renal Clear Cell Carcinoma |
| OncoTree Code | CCRCC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001687_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | VHL | p.Leu89His (c.266T>A) | Unspecified | - | PubMed=7915601 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
9,12
D16S539
9
D18S51
13,15
D21S11
30.2
D3S1358
18
D5S818
9,12
D7S820
9
D8S1179
12
FGA
22
Penta D
13
Penta E
11,13
TH01
9.3
TPOX
8
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Data for identification of GPI-anchored peptides and omega-sites in cancer cell lines.
Masuishi Y., Kimura Y., Arakawa N., Hirano H.
Data Brief 7:1302-1305(2016).
Identification of glycosylphosphatidylinositol-anchored proteins and omega-sites using TiO2-based affinity purification followed by hydrogen fluoride treatment.
Masuishi Y., Kimura Y., Arakawa N., Hirano H.
J. Proteomics 139:77-83(2016).
Mutations of the VHL tumour suppressor gene in renal carcinoma.";
Linehan W.M.
Nat. Genet. 7:85-90(1994).