UM-RC-7Homo sapiens (Human)Cancer cell line
Also known as: University of Michigan-Renal Carcinoma-7, UMRC7, UMRC-7
🤖 AI SummaryBased on 2 publications
Quick Overview
Human renal carcinoma cell line with clear cell morphology and VHL mutations.
Detailed Summary
UM-RC-7 is a human renal carcinoma cell line established from a primary tumor. It exhibits clear cell morphology and has been associated with VHL gene mutations, which are critical in renal tumorigenesis. The cell line has been used in studies to investigate the molecular mechanisms of renal cancer, including loss of heterozygosity (LOH) and somatic mutations. UM-RC-7 has been characterized for its growth properties, chromosomal abnormalities, and cell surface antigen expression. It is one of five renal carcinoma cell lines established in long-term culture, showing consistent features such as cytoplasmic granules and variable reactivity with monoclonal antibodies. The cell line is free from contamination and has been used in nude mouse tumor formation studies.
Research Applications
Renal carcinoma researchVHL gene mutation analysisTumor formation in nude miceCell surface antigen characterization
Key Characteristics
Clear cell morphologyVHL mutationsLoss of heterozygosity (LOH)Chromosomal abnormalitiesCell surface antigen expression
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2742 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Kidney[UBERON:UBERON_0002113] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Renal cell carcinoma |
|---|---|
| Lineage | Kidney |
| Subtype | Renal Cell Carcinoma |
| OncoTree Code | RCC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001688_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | VHL | p.Pro61Alafs*61 (c.180_208del) | Unspecified | - | PubMed=7915601 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
8,11
D16S539
11
D18S51
13,14,19
D19S433
14,15,16.2
D21S11
31.2,33.2
D2S1338
17,25
D3S1358
15
D5S818
12
D7S820
10
D8S1179
13,14
FGA
24,25
Penta D
9,12
Penta E
7,9
TH01
8,9
TPOX
8
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Mutations of the VHL tumour suppressor gene in renal carcinoma.";
Linehan W.M.
Nat. Genet. 7:85-90(1994).