UM-UC-1Homo sapiens (Human)Cancer cell line
Also known as: University of Michigan-Urothelial Carcinoma-1, UMUC1
Quick Overview
Human bladder cancer cell line with transitional cell carcinoma origin, used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_2743 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 26 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | black_or_african_american |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | ECACC |
|---|---|
| Source ID | ACH-000834_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRD1 | p.Gln340Ter (c.1018C>T) | Heterozygous | - | PubMed=27270441 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.
Tsang S.X., Cai Z.-M., Wu S., Dean M., Costello J.C., Theodorescu D.
Oncogene 36:35-46(2017).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
Chanock S.J., Valencia A., Real F.X.
BMC Genomics 16:403.1-403.16(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
Kwiatkowski D.J.
J. Pathol. 230:17-27(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
The use of short tandem repeat profiling to characterize human bladder cancer cell lines.
Chiong E., Dadbin A., Harris L.D., Sabichi A.L., Grossman H.B.
J. Urol. 181:2737-2748(2009).
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.
Czerniak B.
J. Natl. Cancer Inst. 100:1401-1411(2008).
Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression.
Zhou J.-H., Benedict W.F., Grossman H.B.
J. Urol. 175:1133-1137(2006).
UM-UC-1 and UM-UC-2: characterization of two new human transitional cell carcinoma lines.
Grossman H.B., Wedemeyer G., Ren L.-Q.
J. Urol. 132:834-837(1984).