UM-UC-11Homo sapiens (Human)Cancer cell line
Also known as: University of Michigan-Urothelial Carcinoma-11, UC-11, UMUC11, UM-UC11
🤖 AI SummaryBased on 5 publications
Quick Overview
Human bladder cancer cell line with known genetic mutations and tumorigenic potential.
Detailed Summary
UM-UC-11 is a human bladder cancer cell line derived from transitional cell carcinoma. It is characterized by specific genetic alterations, including mutations in the TP53 gene, which are common in urothelial cancers. The cell line has been used in studies investigating the role of genetic mutations in bladder cancer progression and response to therapies. UM-UC-11 has demonstrated tumorigenic potential in vivo, forming tumors in immunocompromised mice, which makes it a valuable model for preclinical research. Additionally, it has been involved in studies related to cell line authentication and cross-contamination, highlighting its importance in ensuring the reliability of experimental results. The cell line's genetic profile and behavior in experimental models make it a key resource for understanding bladder cancer biology and developing targeted therapies.
Research Applications
Genetic mutation analysisTumorigenicity studiesCell line authenticationTherapeutic response evaluation
Key Characteristics
TP53 mutationsTumorigenic potential in vivoUsed in cross-contamination studies
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2745 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Urinary bladder[UBERON:UBERON_0001255] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001413_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10
D13S317
11,14
D16S539
11
D18S51
13
D21S11
30
D3S1358
15,16
D5S818
12
D7S820
8,12
D8S1179
11,13
FGA
20,23
Penta D
11,13
Penta E
7,10
TH01
6,9
TPOX
9
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
Chanock S.J., Valencia A., Real F.X.
BMC Genomics 16:403.1-403.16(2015).
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Eur. Urol. 65:360-366(2014).
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
Kwiatkowski D.J.
J. Pathol. 230:17-27(2013).
The use of short tandem repeat profiling to characterize human bladder cancer cell lines.
Chiong E., Dadbin A., Harris L.D., Sabichi A.L., Grossman H.B.
J. Urol. 181:2737-2748(2009).
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.
Czerniak B.
J. Natl. Cancer Inst. 100:1401-1411(2008).