UM-UC-13Homo sapiens (Human)Cancer cell line

Also known as: University of Michigan-Urothelial Carcinoma-13, UC-13, UMUC13

🤖 AI SummaryBased on 6 publications

Quick Overview

Human bladder cancer cell line with known genetic alterations.

Detailed Summary

UM-UC-13 is a human bladder cancer cell line derived from transitional cell carcinoma. It is characterized by specific genetic alterations, including mutations in the TERT promoter and other key cancer-related genes. The cell line has been used in studies to investigate the molecular mechanisms of bladder cancer and to model tumor biology for drug response studies. Research has shown that UM-UC-13 exhibits features consistent with muscle-invasive bladder cancer, including alterations in pathways such as PI3K/mTOR and BRCA DNA repair. The cell line has also been used to study the impact of genomic aberrations on drug sensitivity and to identify potential therapeutic targets.

Research Applications

Molecular analysis of urothelial cancerDrug response modelingGenomic aberration studiesPathway activity analysis

Key Characteristics

TERT promoter mutationsPI3K/mTOR pathway alterationsBRCA DNA repair pathway alterationsGenomic instability markers

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2746
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Bladder carcinoma
Lineage	Bladder/Urinary Tract
Subtype	Bladder Urothelial Carcinoma
OncoTree Code	BLCA

DepMap Information

Source Type	Sigma-Aldrich
Source ID	ACH-001407_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

8,12

D16S539

D18S51

D21S11

27,30

D3S1358

D5S818

9,13

D7S820

D8S1179

FGA

Penta D

9,13

Penta E

7,16

TH01

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Systematic review: characteristics and preclinical uses of bladder cancer cell lines.

Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.

Bladder Cancer 4:169-183(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.

Tsang S.X., Cai Z.-M., Wu S., Dean M., Costello J.C., Theodorescu D.

Oncogene 36:35-46(2017).

DOI PubMed PMC

The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.

Chanock S.J., Valencia A., Real F.X.

BMC Genomics 16:403.1-403.16(2015).

DOI PubMed PMC

Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.

Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.

Eur. Urol. 65:360-366(2014).

DOI PubMed

The use of short tandem repeat profiling to characterize human bladder cancer cell lines.

Chiong E., Dadbin A., Harris L.D., Sabichi A.L., Grossman H.B.

J. Urol. 181:2737-2748(2009).

DOI PubMed PMC

Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.

Czerniak B.

J. Natl. Cancer Inst. 100:1401-1411(2008).

DOI PubMed PMC

Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression.

Zhou J.-H., Benedict W.F., Grossman H.B.

J. Urol. 175:1133-1137(2006).

DOI PubMed

Web Resources

tcpaportal.org synapse.org