UM-UC-16Homo sapiens (Human)Cancer cell line
Also known as: University of Michigan-Urothelial Carcinoma-16, UMUC16
🤖 AI SummaryBased on 3 publications
Quick Overview
Human bladder cancer cell line with known genetic alterations and tumorigenic potential.
Detailed Summary
UM-UC-16 is a human bladder cancer cell line derived from transitional cell carcinoma. It has been characterized for its genetic profile, including mutations in the TP53 gene, which is a critical tumor suppressor. The cell line exhibits tumorigenic properties, as it forms tumors in immunodeficient mice, making it a valuable tool for in vivo studies. UM-UC-16 has been used in research to investigate the molecular mechanisms of bladder cancer, including the role of TP53 mutations in tumor progression. Additionally, it has been part of panels for drug sensitivity and molecular profiling, contributing to the understanding of bladder cancer biology and therapeutic strategies.
Research Applications
Tumorigenicity studies in immunodeficient miceMolecular profiling for drug sensitivityInvestigation of TP53 mutations in tumor progression
Key Characteristics
Tumorigenic in vivoTP53 mutations identifiedPart of drug sensitivity panels
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2748 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Urinary bladder[UBERON:UBERON_0001255] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Unknown |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001409_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,13
D13S317
8,11
D16S539
11,12
D18S51
13,18
D21S11
30,32
D3S1358
16,17
D5S818
11,12
D7S820
11
D8S1179
13,15
FGA
22,24.2
Penta D
11,12
Penta E
13,17
TH01
6
TPOX
8,10
vWA
15,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
The use of short tandem repeat profiling to characterize human bladder cancer cell lines.
Chiong E., Dadbin A., Harris L.D., Sabichi A.L., Grossman H.B.
J. Urol. 181:2737-2748(2009).