UM-UC-4Homo sapiens (Human)Cancer cell line
Also known as: University of Michigan-Urothelial Carcinoma-4, UMUC4
🤖 AI SummaryBased on 2 publications
Quick Overview
Human bladder cancer cell line for research.
Detailed Summary
UM-UC-4 is a human bladder cancer cell line established from a lymph node specimen. It was derived from a patient with an urachal carcinoma and has been used in studies involving urothelial tumor cultures. The cell line demonstrates aneuploidy and has been shown to form tumors in athymic nude mice. It is part of a series of cell lines that have contributed to understanding the genetic and cytogenetic characteristics of bladder cancer. UM-UC-4 has a doubling time of approximately 32 hours and has been utilized in in vitro and in vivo models for bladder cancer research.
Research Applications
In vitro and in vivo tumor growth studiesCytogenetic analysis of bladder cancerEvaluation of cell line characteristics for cancer research
Key Characteristics
Aneuploid karyotypeTumor formation in nude miceDoubling time of approximately 32 hours
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2749 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001410_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Leu130Arg (c.389T>G) | Unspecified | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
9
D16S539
13
D18S51
16
D21S11
29
D3S1358
15,16
D5S818
11
D7S820
9,13
D8S1179
14
FGA
24
Penta D
12
Penta E
12,13
TH01
9.3
TPOX
8
vWA
17,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
Chanock S.J., Valencia A., Real F.X.
BMC Genomics 16:403.1-403.16(2015).