UM-UC-5Homo sapiens (Human)Cancer cell line
Also known as: University of Michigan-Urothelial Carcinoma-5, UMUC5
🤖 AI SummaryBased on 3 publications
Quick Overview
Human bladder cancer cell line with TERT mutations, used in bladder cancer research.
Detailed Summary
UM-UC-5 is a human bladder cancer cell line derived from a transitional cell carcinoma. It is known for harboring TERT promoter mutations, which are prevalent in urothelial bladder cancer. These mutations, particularly C228T, are associated with increased telomerase activity and have been linked to tumor progression. The cell line has been utilized in studies investigating the role of TERT mutations in bladder cancer diagnosis and prognosis. UM-UC-5 has also been used to explore the potential of urine-based biomarkers for detecting bladder cancer recurrence. Research involving this cell line has contributed to understanding the molecular mechanisms underlying bladder cancer and has supported the development of targeted therapies.
Research Applications
TERT promoter mutation analysisUrine-based biomarker developmentBladder cancer diagnosis and prognosis
Key Characteristics
TERT C228T mutationTransitional cell carcinoma originUsed in molecular profiling studies
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2750 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Urinary bladder[UBERON:UBERON_0001255] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Squamous Cell Carcinoma |
| OncoTree Code | BLSC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001411_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Trp53Ter (c.159G>A) | Unspecified | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
8,12
D16S539
11,13
D18S51
13,16
D21S11
32.2
D3S1358
15
D5S818
13
D7S820
10,12
D8S1179
12,13
FGA
20
Penta D
9
Penta E
15,17
TH01
7,9
TPOX
9,11
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
Chanock S.J., Valencia A., Real F.X.
BMC Genomics 16:403.1-403.16(2015).
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Eur. Urol. 65:360-366(2014).