UM-UC-6Homo sapiens (Human)Cancer cell line

Also known as: University of Michigan-Urothelial Carcinoma-6, UC-6, UMUC6, UM-UC6

🤖 AI SummaryBased on 6 publications

Quick Overview

Human bladder cancer cell line with known genetic alterations and tumorigenic potential.

Detailed Summary

UM-UC-6 is a human bladder cancer cell line derived from transitional cell carcinoma. It has been characterized for its genetic alterations, including mutations in key cancer-related genes such as TP53 and TERT. The cell line exhibits tumorigenic potential in vivo, forming tumors in athymic nude mice. It is used in research to study bladder cancer biology, drug response, and molecular pathways. UM-UC-6 has been involved in studies related to genomic aberrations, copy number variations, and their implications in cancer progression. Its use in preclinical models provides insights into bladder cancer mechanisms and therapeutic strategies.

Research Applications

Genomic and molecular profilingTumorigenicity studiesDrug response and pharmacogenomicsCopy number variation analysis

Key Characteristics

TP53 mutationTERT promoter mutationTumorigenic in vivoGenomic instability

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2751
Species	Homo sapiens (Human)
Tissue Source	Urinary bladder[UBERON:UBERON_0001255]

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Bladder carcinoma
Lineage	Bladder/Urinary Tract
Subtype	Bladder Urothelial Carcinoma
OncoTree Code	BLCA

DepMap Information

Source Type	Sigma-Aldrich
Source ID	ACH-001414_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Glu198Ter (c.592G>T)	Heterozygous	-	PubMed=24023729

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

13,14

D16S539

9,13

D18S51

D21S11

31.2

D3S1358

15,18

D5S818

11,13

D7S820

8,10

D8S1179

10,11

FGA

21,24

Penta D

Penta E

12,13

TH01

TPOX

9,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Systematic review: characteristics and preclinical uses of bladder cancer cell lines.

Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.

Bladder Cancer 4:169-183(2018).

DOI PubMed PMC

Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.

Tsang S.X., Cai Z.-M., Wu S., Dean M., Costello J.C., Theodorescu D.

Oncogene 36:35-46(2017).

DOI PubMed PMC

The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.

Chanock S.J., Valencia A., Real F.X.

BMC Genomics 16:403.1-403.16(2015).

DOI PubMed PMC

TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.

Kwiatkowski D.J.

J. Pathol. 230:17-27(2013).

DOI PubMed

The use of short tandem repeat profiling to characterize human bladder cancer cell lines.

Chiong E., Dadbin A., Harris L.D., Sabichi A.L., Grossman H.B.

J. Urol. 181:2737-2748(2009).

DOI PubMed PMC

Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.

Czerniak B.

J. Natl. Cancer Inst. 100:1401-1411(2008).

DOI PubMed PMC

Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression.

Zhou J.-H., Benedict W.F., Grossman H.B.

J. Urol. 175:1133-1137(2006).

DOI PubMed

Improved growth of human urothelial carcinoma cell cultures.";

Grossman H.B., Wedemeyer G., Ren L.-Q., Wilson G.N., Cox B.

J. Urol. 136:953-959(1986).

DOI PubMed

Web Resources

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