UM-UC-7Homo sapiens (Human)Cancer cell line
Also known as: University of Michigan-Urothelial Carcinoma-7, UMUC7
🤖 AI SummaryBased on 4 publications
Quick Overview
Human bladder cancer cell line with TERT mutations, used in urothelial cancer research.
Detailed Summary
UM-UC-7 is a human bladder cancer cell line derived from transitional cell carcinoma. It is characterized by the presence of TERT promoter mutations, specifically C228T, which are common in urothelial bladder cancer. These mutations are associated with early genetic events in urothelial carcinogenesis and are not linked to clinical outcomes. The cell line has been utilized in studies investigating the role of TERT mutations in tumor detection through urine analysis, showing potential for non-invasive surveillance. UM-UC-7 is also part of in vitro and in vivo models for bladder cancer research, contributing to understanding tumor biology and therapeutic strategies.
Research Applications
TERT mutation analysisUrine-based tumor detectionIn vitro and in vivo bladder cancer models
Key Characteristics
TERT promoter mutations (C228T)Transitional cell carcinoma originUsed in non-invasive surveillance studies
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2752 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Urinary bladder[UBERON:UBERON_0001255] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001415_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg213Ter (c.637C>T) | Unspecified | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10
D13S317
12
D16S539
10,11
D18S51
13
D21S11
31,32
D3S1358
15
D5S818
12
D7S820
10,11
D8S1179
14
FGA
20,22
Penta D
12,13
Penta E
7
TH01
9
TPOX
8,11
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
Chanock S.J., Valencia A., Real F.X.
BMC Genomics 16:403.1-403.16(2015).
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Eur. Urol. 65:360-366(2014).
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
Kwiatkowski D.J.
J. Pathol. 230:17-27(2013).
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.
Czerniak B.
J. Natl. Cancer Inst. 100:1401-1411(2008).