VP229Homo sapiens (Human)Cancer cell line
Also known as: BrCL18, VP 229
🤖 AI SummaryBased on 5 publications
Quick Overview
Breast cancer cell line with chromosomal abnormalities and potential for research in genetic instability and tumor progression.
Detailed Summary
VP229 is a breast cancer cell line derived from a primary tumor, showing significant chromosomal abnormalities. It has been studied for its genetic instability and role in tumor progression. The cell line exhibits complex karyotype patterns, including multiple translocations and aneuploidy, which are common in breast carcinomas. Research on VP229 has contributed to understanding the molecular mechanisms of breast cancer, particularly in relation to chromosomal rearrangements and their implications in tumorigenesis. The cell line is used in studies involving comparative genomic hybridization (CGH) and spectral karyotyping to analyze genetic alterations. VP229's characteristics make it a valuable tool for investigating the genetic basis of breast cancer and developing targeted therapies.
Research Applications
Analysis of chromosomal abnormalities in breast cancerStudy of genetic instability and tumor progressionComparative genomic hybridization (CGH) and spectral karyotypingInvestigation of translocations and chromosomal rearrangements
Key Characteristics
Complex karyotype with multiple translocationsAneuploid natureUsed in molecular cytogenetic studiesRelevant for understanding breast cancer genetics
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2754 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 47 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Invasive breast carcinoma of no special type |
|---|---|
| Lineage | Breast |
| Subtype | Breast Invasive Ductal Carcinoma |
| OncoTree Code | IDC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001419_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Tyr220Cys (c.659A>G) | Unspecified | - | PubMed=21173094 |
| MutationSimple | EP300 | p.Asn1700Thrfs*9 (c.5099delA) | Hemizygous | - | PubMed=10700188 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
11,13
D16S539
11,12
D18S51
16
D19S433
13
D21S11
29
D2S1338
18,25
D3S1358
16,18
D5S818
11
D7S820
10,12
D8S1179
10,13
FGA
18
Penta D
10
Penta E
13,17
TH01
7
TPOX
8
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Edwards P.A.W., Caldas C.
Carcinogenesis 26:923-930(2005).
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Edwards P.A.W., Chaffanet M.
Genes Chromosomes Cancer 37:333-345(2003).
Molecular cytogenetic analysis of breast cancer cell lines.";
Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.
Br. J. Cancer 83:1309-1317(2000).
Mutations truncating the EP300 acetylase in human cancers.";
Delhanty J.D.A., Ponder B.A.J., Kouzarides T., Caldas C.
Nat. Genet. 24:300-303(2000).