VP267Homo sapiens (Human)Cancer cell line
Also known as: VP 267
🤖 AI SummaryBased on 3 publications
Quick Overview
Human breast cancer cell line with complex karyotype and chromosomal abnormalities.
Detailed Summary
VP267 is a human breast cancer cell line derived from a primary tumor. It exhibits a highly aneuploid karyotype with numerous chromosomal translocations and structural rearrangements. The cell line shows significant chromosomal instability, including gains and losses of multiple chromosomes, and is characterized by complex multiple translocations involving chromosomes 8, 11, and others. VP267 has been used in studies analyzing chromosomal abnormalities in breast cancer, providing insights into the genetic instability and evolution of tumor karyotypes. Its karyotype is representative of the genetic diversity observed in breast carcinomas, making it a valuable resource for research on chromosomal alterations in breast cancer.
Research Applications
Analysis of chromosomal abnormalities in breast cancerStudy of genetic instability and karyotype evolutionInvestigation of complex chromosomal translocations
Key Characteristics
Highly aneuploid karyotypeNumerous chromosomal translocationsSignificant chromosomal instabilityComplex multiple translocations involving chromosomes 8 and 11
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2755 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 48 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Subtype Features | ER-, PR- |
Disease Information
| Disease | Invasive breast carcinoma of no special type |
|---|---|
| Lineage | Breast |
| Subtype | Breast Invasive Ductal Carcinoma |
| OncoTree Code | IDC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001705_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Tyr220Cys (c.659A>G) | Unspecified | - | PubMed=21173094 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
11,13
D16S539
11,12
D18S51
16
D19S433
13
D21S11
29
D2S1338
25
D3S1358
16,18
D5S818
11
D7S820
10,12
D8S1179
10,13
FGA
18
Penta D
10
Penta E
13,17
TH01
7
TPOX
8
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
USP7 small-molecule inhibitors interfere with ubiquitin binding.";
Murray J., Maurer T., Wertz I.E.
Nature 550:534-538(2017).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Edwards P.A.W., Caldas C.
Carcinogenesis 26:923-930(2005).
Molecular cytogenetic analysis of breast cancer cell lines.";
Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.
Br. J. Cancer 83:1309-1317(2000).