WM266-4Homo sapiens (Human)Cancer cell line
Also known as: WC00097, WM266mel, WM-266-mel, WM266, WM 2664, WM2664, WM-2664, WM 266-4, WM-266-4
Quick Overview
Human melanoma cell line with BRAF mutations and potential for cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_2765 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Right thigh, skin[UBERON:UBERON_0004262] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001239_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TERT | c.1-146C>T (c.250C>T) (C250T) | Unspecified | In promoter | PubMed=31068700 |
| MutationSimple | BRAF | p.Val600Asp (c.1799_1800delTGinsAT) | Heterozygous | - | Unknown, Unknown, PubMed=29492214, PubMed=23851445, PubMed=19799798, PubMed=12068308, Wistar |
| Gene deletion | PTEN | - | Hemizygous | - | Wistar |
| Gene deletion | CDKN2B | - | Homozygous | - | PubMed=35933914 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Genetic alterations in main candidate genes during melanoma progression.
Manca A., Botti G., Ascierto P.A., Lissia A., Cossu A., Palmieri G.
Oncotarget 9:8531-8541(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: from oncogenic addiction to druggable targets.
Tsangaris G.T., Stravopodis D.J.
PLoS ONE 12:E0171512-E0171512(2017).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Borg A., Pawelec G., Guldberg P.
Mol. Cancer Res. 11:1166-1178(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Induction of arginosuccinate synthetase (ASS) expression affects the antiproliferative activity of arginine deiminase (ADI) in melanoma cells.
Palmieri G.
Oncol. Rep. 25:1495-1502(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy.
Palomba G., Palmieri G.
BMC Cancer 9:352.1-352.11(2009).
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.
Sharpless N.E.
Cancer Res. 67:1502-1512(2007).
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Garrido F.
Cancer Immunol. Immunother. 54:141-148(2005).
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J.
Oncogene 23:8796-8804(2004).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor.
Falcinelli S., Zambruno G., D'Atri S.
J. Invest. Dermatol. 115:1000-1007(2000).
Characteristics of cultured human melanocytes isolated from different stages of tumor progression.
Koprowski H.
Cancer Res. 45:5670-5676(1985).
Primary melanoma cells of the vertical growth phase: similarities to metastatic cells.
Clark W.H. Jr., Koprowski H.
J. Natl. Cancer Inst. 74:283-289(1985).
Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.
Herlyn M., Rodeck U., Koprowski H.
Proc. Natl. Acad. Sci. U.S.A. 83:7197-7200(1986).