Tera-1Homo sapiens (Human)Cancer cell line
Also known as: TERA1, TERA-1
🤖 AI SummaryBased on 4 publications
Quick Overview
Human teratocarcinoma cell line with potential for research in germ cell tumors and oncogenes.
Detailed Summary
Tera-1 is a human teratocarcinoma cell line derived from testicular tumors, commonly used in cancer research. It has been studied for its genetic characteristics, including mutations in genes such as FGFR3, AKT1, and PIK3CA, which are associated with cisplatin resistance in germ cell tumors. The cell line has also been investigated for retrovirus-like particles, contributing to understanding of viral interactions in cancer. Tera-1 is notable for its role in studies on oncogenic pathways and drug resistance mechanisms.
Research Applications
Cisplatin resistance in germ cell tumorsOncogene mutations (FGFR3, AKT1, PIK3CA)Retrovirus-like particle production
Key Characteristics
Spontaneous production of retrovirus-like particlesMutations associated with cisplatin resistanceUsed in studies of germ cell tumor biology
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2776 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 47 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Embryonal carcinoma |
|---|---|
| Lineage | Testis |
| Subtype | Embryonal Carcinoma |
| OncoTree Code | EMBCA |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001671_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
12
D16S539
10,12
D18S51
15,16
D19S433
14,15
D21S11
29,32.2,33.2
D2S1338
17
D3S1358
15
D5S818
11,13
D7S820
9,10
D8S1179
11,15
FGA
21,25
Penta D
10,13
Penta E
7,15
TH01
7,8
TPOX
8
vWA
14
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors.
Reuter V.E., Bosl G.J., Chaganti R.S.K., Solit D.B.
Clin. Cancer Res. 20:3712-3720(2014).
Human teratocarcinomas cultured in vitro produce unique retrovirus-like viruses.
Lower R., Lower J., Frank H., Harzmann R., Kurth R.
J. Gen. Virol. 65:887-898(1984).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors.
Fogh J.
Natl. Cancer Inst. Monogr. 49:5-9(1978).
New human tumor cell lines.";
Fogh J., Trempe G.L.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.115-159; Springer; New York; USA (1975).