Tera-2Homo sapiens (Human)Cancer cell line

Also known as: Tera II, Tera 2, TERA-2

🤖 AI SummaryBased on 5 publications

Quick Overview

Human testicular teratocarcinoma cell line for cancer research.

Detailed Summary

Tera-2 is a human testicular teratocarcinoma cell line derived from testicular tumors. It is used in research to study the characteristics of teratocarcinomas, including their potential to produce retrovirus-like particles. The cell line has been utilized in studies examining the morphological and biochemical properties of these cells, as well as their behavior in culture and in vivo. Tera-2 cells have been shown to produce HTD particles, which are retrovirus-like particles with unique characteristics. These particles are not infectious and do not share immunological similarities with known retroviruses. The cell line has also been used to investigate the effects of various treatments and the genetic stability of the cells over time. Tera-2 is a valuable tool for understanding the biology of testicular tumors and their potential for malignancy.

Research Applications

Study of retrovirus-like particle productionAnalysis of cell morphology and biochemistryInvestigation of tumor biology and malignancyEvaluation of genetic stability and mutations

Key Characteristics

Produces HTD particlesNot infectiousLacks immunological similarity to known retrovirusesUsed in cancer research and tumor biology studies

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2777
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	22
Age Category	Adult
Sex	Male

Disease Information

Disease	Embryonal carcinoma
Lineage	Testis
Subtype	Embryonal Carcinoma
OncoTree Code	EMBCA

DepMap Information

Source Type	ATCC
Source ID	ACH-001672_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

D16S539

11,12,13

D18S51

D19S433

14,15.2

D21S11

30,31

D2S1338

22,25

D3S1358

D5S818

9,12

D7S820

10,12

D8S1179

13,15

FGA

Penta D

12,13

Penta E

5,14

TH01

9.3

TPOX

vWA

18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Molecular basis of cisplatin resistance in testicular germ cell tumors.

Buchler T., Trka J., Boublikova L.

Cancers (Basel) 11:1316.1-1316.18(2019).

DOI PubMed PMC

Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.

Wright W.C., Daniels W.P., Fogh J.

J. Natl. Cancer Inst. 66:239-247(1981).

DOI PubMed

Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro.

Dracopoli N.C., Fogh J.

Lab. Invest. 50:147-162(1984).

PubMed

Human urologic cancer cell lines.";

Williams R.D.

Invest. Urol. 17:359-363(1980).

PubMed

Human teratocarcinomas cultured in vitro produce unique retrovirus-like viruses.

Lower R., Lower J., Frank H., Harzmann R., Kurth R.

J. Gen. Virol. 65:887-898(1984).

DOI PubMed

A comparative study of eight cell lines derived from human testicular teratocarcinoma.

Andrews P.W., Bronson D.L., Benham F.J., Strickland S., Knowles B.B.

Int. J. Cancer 26:269-280(1980).

DOI PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Human teratocarcinomas.";

Andrews P.W.

Biochim. Biophys. Acta 948:17-36(1988).

DOI PubMed

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

DOI PubMed

Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors.

Fogh J.

Natl. Cancer Inst. Monogr. 49:5-9(1978).

PubMed

New human tumor cell lines.";

Fogh J., Trempe G.L.

(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.115-159; Springer; New York; USA (1975).

DOI