HO-1-u-1Homo sapiens (Human)Cancer cell line

Also known as: Ueda-1, Ho1u1, HO1u1, HO1U1, Ho-1U1, HO1-U1, HO1-U-1, Ho-1-u-1, HO-1-U-1, HO1-UI

🤖 AI SummaryBased on 9 publications

Quick Overview

Human squamous cell carcinoma cell line for cancer research.

Detailed Summary

The HO-1-u-1 cell line is a human squamous cell carcinoma cell line derived from the floor of the mouth, commonly used in cancer research. It has been utilized in studies related to oral cancer, including investigations into tumor suppressor genes like FAT and the role of genetic diversity in cancer research. This cell line is also employed in evaluating sublingual drug delivery models and has been part of studies examining the effects of pH, osmolarity, and permeation enhancers on drug absorption. Additionally, it has been used in research on the association of human papillomavirus (HPV) with oral carcinogenesis, particularly focusing on HPV-16 and HPV-18. The cell line is noted for its utility in understanding the molecular mechanisms of cancer progression and in developing targeted therapies.

Research Applications

Cancer researchDrug delivery studiesHPV infection studiesGenetic diversity in cancerTumor suppressor gene analysis

Key Characteristics

Used in oral cancer studiesUtilized for sublingual drug delivery modelsAssociated with FAT gene mutationsInvolved in HPV-16 and HPV-18 research

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2784
Species	Homo sapiens (Human)
Tissue Source	Salivary gland, sublingual gland[UBERON:UBERON_0001832]

Donor Information

Age	72
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the oral cavity
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	RIKEN
Source ID	ACH-002045_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

D5S818

D7S820

9,10

TH01

TPOX

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.

McDermott U., Garnett M.J., Cheong S.-C.

eLife 9:e57761.1-e57761.34(2020).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Establishment and first characterization of a sublingual epithelial and immune cell co-culture model.

Vacher G., Sublet E., Gurny R., Borchard G.

Int. J. Pharm. 482:61-67(2015).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

HO-1-u-1 model for screening sublingual drug delivery -- influence of pH, osmolarity and permeation enhancer.

Wang Y.-F., Zuo Z., Chow M.S.-S.

Int. J. Pharm. 370:68-74(2009).

DOI PubMed

Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.

Hamakawa H.

Oncogene 26:5300-5308(2007).

DOI PubMed

Evaluation of HO-1-u-1 cell line as an in vitro model for sublingual drug delivery involving passive diffusion -- initial validation studies.

Wang Y.-F., Zuo Z., Lee K.K.-H., Chow M.S.-S.

Int. J. Pharm. 334:27-34(2007).

DOI PubMed

Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.

Sugiyama M., Bhawal U.K., Dohmen T., Ono S., Miyauchi M., Ishikawa T.

Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Establishment of human tumor cell line (Ueda-1) derived from squamous cell carcinoma of the floor of the mouth.

Miyauchi S., Moroyama T., Sakamoto T., Okamoto T., Takada K.

Nihon Koku Geka Gakkai Zasshi 31:1347-1351(1985).

DOI