JHH-1Homo sapiens (Human)Cancer cell line

Also known as: JHH1, Jhh-1

🤖 AI SummaryBased on 10 publications

Quick Overview

Human hepatocellular carcinoma cell line with p53 mutations and chemosensitivity profiles.

Detailed Summary

JHH-1 is a human hepatocellular carcinoma (HCC) cell line derived from liver tissue. It is characterized by specific genetic alterations, including mutations in the p53 gene, which are associated with tumorigenicity and resistance to certain chemotherapeutic agents. The cell line has been used in studies to evaluate drug sensitivity and identify potential therapeutic targets. JHH-1 exhibits distinct patterns of gene expression and copy number variations, contributing to its utility in cancer research. Its molecular profile, including the presence of p53 mutations, makes it a valuable model for studying HCC progression and treatment responses.

Research Applications

Chemosensitivity profilingp53 mutation analysisGene expression studiesCopy number variation analysis

Key Characteristics

p53 mutationsChemosensitivity to various drugsGene expression profilesCopy number variations
Generated on 6/19/2025

Basic Information

Database IDCVCL_2785
SpeciesHomo sapiens (Human)

Donor Information

Age50
Age CategoryAdult
SexMale
Raceasian

Disease Information

DiseaseAdult hepatocellular carcinoma
LineageLiver
SubtypeHepatocellular Carcinoma
OncoTree CodeHCC

DepMap Information

Source TypeHSRRB
Source IDACH-000620_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12,13
D13S317
8,10
D16S539
9,13
D5S818
11
D7S820
9
TH01
7
TPOX
8,11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

A pharmacogenomic landscape in human liver cancers.";

Hui L.-J.

Cancer Cell 36:179-193.e11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.

Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.

Gastroenterology 157:760-776(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.

Xu J.-C.

Hepatology 58:706-717(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Check your cultures! A list of cross-contaminated or misidentified cell lines.

Freshney R.I.

Int. J. Cancer 127:1-8(2010).

Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.

Yamori T.

Mol. Cancer Ther. 4:399-412(2005).

Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.

Gao C., Ohashi R., Pu H., Inoue Y., Tsuji T., Miyazaki M., Namba M.

Oncol. Rep. 6:1267-1271(1999).

Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.

Fukaya K.-i., Ishioka C., Namba M.

Acta Med. Okayama 51:261-265(1997).

Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.

Kosaka T., Tsuji T., Namba M.

J. Med. Virol. 48:133-140(1996).

Integration of hepatitis B virus DNA into cells of six established human hepatocellular carcinoma cell lines.

Shimizu K., Niiya M., Kameda H., Fujita K., Ohno T.

Hepato-Gastroenterol. 37:457-460(1990).

The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.

Ohashi R., Namba M.

Tissue Cult. Res. Commun. 16:173-178(1997).