Back to Cell Types

JHH-4Homo sapiens (Human)Cancer cell line

Also known as: JHH4, Jhh-4

🤖 AI SummaryBased on 10 publications

Quick Overview

Human hepatocellular carcinoma cell line with p53 mutations and potential for cancer research.

Detailed Summary

JHH-4 is a human hepatocellular carcinoma (HCC) cell line derived from liver tissue. It is characterized by the presence of p53 gene mutations, which are frequently observed in HCC and contribute to tumorigenesis. The cell line exhibits specific genetic alterations, including mutations in the p53 gene, which may influence its behavior in experimental models. JHH-4 is used in studies related to liver cancer, focusing on the molecular mechanisms of tumorigenesis and drug sensitivity. Research on this cell line has contributed to understanding the role of p53 mutations in cancer progression and therapeutic responses.

Research Applications

Cancer researchMolecular mechanisms of tumorigenesisDrug sensitivity studies

Key Characteristics

p53 gene mutationsHepatocellular carcinoma origin

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2787
Species	Homo sapiens (Human)

Donor Information

Age	51
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Adult hepatocellular carcinoma
Lineage	Liver
Subtype	Hepatocellular Carcinoma
OncoTree Code	HCC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000476_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg249Ser (c.747G>T)	Unspecified	-	PubMed=11799138, CelloPub=CLPUB00439
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	ACVR2A	p.Cys78Ter (c.234T>A)	Unspecified	-	PubMed=31378681

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,12

D13S317

12

D16S539

12,13

D18S51

13,16

D21S11

31.2,32.2

D3S1358

15,16

D5S818

9,13

D7S820

10,12

D8S1179

17

FGA

22

Penta D

9,12

Penta E

5,12

TH01

6,9

TPOX

8,11

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

A pharmacogenomic landscape in human liver cancers.";

Hui L.-J.

Cancer Cell 36:179-193.e11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.

Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.

Gastroenterology 157:760-776(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations.

Cevik D., Yildiz G., Ozturk M.

World J. Gastroenterol. 21:311-317(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.

Xu J.-C.

Hepatology 58:706-717(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.

Gao C., Ohashi R., Pu H., Inoue Y., Tsuji T., Miyazaki M., Namba M.

Oncol. Rep. 6:1267-1271(1999).

Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.

Fukaya K.-i., Ishioka C., Namba M.

Acta Med. Okayama 51:261-265(1997).

Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.

Kosaka T., Tsuji T., Namba M.

J. Med. Virol. 48:133-140(1996).

Establishment and characterization of a human hepatocellular carcinoma cell line JHH-4.

Hasumura S., Sujino H., Nagamori S., Kameda H.

Hum. Cell 1:98-100(1988).

Combination therapy of hyperthermia and other methods in liver and bile tract cancers -- evaluation of these methods using cancer cell lines in vitro.

Shimizu K., Niiya M., Kameda H.

Gan To Kagaku Ryoho 16:1905-1912(1989).

Integration of hepatitis B virus DNA into cells of six established human hepatocellular carcinoma cell lines.

Shimizu K., Niiya M., Kameda H., Fujita K., Ohno T.

Hepato-Gastroenterol. 37:457-460(1990).

The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.

Ohashi R., Namba M.

Tissue Cult. Res. Commun. 16:173-178(1997).

Web Resources

lccl.zucmanlab.com tcpaportal.org