JHH-6Homo sapiens (Human)Cancer cell line

Also known as: JHH6, Jhh-6

🤖 AI SummaryBased on 8 publications

Quick Overview

Human hepatocellular carcinoma cell line with p53 mutations and MT1-MMP expression.

Detailed Summary

JHH-6 is a human hepatocellular carcinoma (HCC) cell line derived from liver tissue. It is characterized by the presence of p53 gene mutations and the expression of membrane-type 1 matrix metalloproteinase (MT1-MMP), which plays a role in tumor invasion and metastasis. The cell line shows invasive properties in vitro and can be used to study the mechanisms of HCC progression. Research on JHH-6 has contributed to understanding the role of MT1-MMP in cancer cell invasion and the impact of HGF on tumor cell behavior. Additionally, JHH-6 has been utilized in studies examining the relationship between genetic alterations and drug sensitivity in cancer models.

Research Applications

Cancer invasion and metastasis studiesMT1-MMP and MMP-2 expression analysisp53 mutation analysisHGF-induced invasion mechanismsDrug sensitivity profiling

Key Characteristics

p53 gene mutationsMT1-MMP expressionInvasive potential in vitroResponse to HGF stimulation
Generated on 6/19/2025

Basic Information

Database IDCVCL_2788
SpeciesHomo sapiens (Human)

Donor Information

Age57
Age CategoryAdult
SexFemale
Raceasian

Disease Information

DiseaseAdult hepatocellular carcinoma
LineageLiver
SubtypeHepatocellular Carcinoma
OncoTree CodeHCC

DepMap Information

Source TypeHSRRB
Source IDACH-000217_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Glu336Aspfs*7 (c.1008_1018delGCGCTTCGAGA)Heterozygous-Unknown, Unknown, PubMed=31378681
MutationSimpleTERTc.1-124C>T (c.228C>T) (C228T)UnspecifiedIn promoterfrom parent cell line Hep-G2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,12
D13S317
11,12,13
D16S539
10
D18S51
20
D19S433
13
D21S11
31,32.2
D2S1338
19,24
D3S1358
17
D5S818
10,11
D7S820
11
D8S1179
12,13
FGA
22
Penta D
10,13
Penta E
15
TH01
7,9
TPOX
8,9
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

A pharmacogenomic landscape in human liver cancers.";

Hui L.-J.

Cancer Cell 36:179-193.e11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.

Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.

Gastroenterology 157:760-776(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.

Xu J.-C.

Hepatology 58:706-717(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase.

Nagamori S., Yamada Y., Saiki I.

Neoplasia 1:424-430(1999).

Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.

Gao C., Ohashi R., Pu H., Inoue Y., Tsuji T., Miyazaki M., Namba M.

Oncol. Rep. 6:1267-1271(1999).

Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.

Fukaya K.-i., Ishioka C., Namba M.

Acta Med. Okayama 51:261-265(1997).

Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.

Kosaka T., Tsuji T., Namba M.

J. Med. Virol. 48:133-140(1996).

Integration of hepatitis B virus DNA into cells of six established human hepatocellular carcinoma cell lines.

Shimizu K., Niiya M., Kameda H., Fujita K., Ohno T.

Hepato-Gastroenterol. 37:457-460(1990).

The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.

Ohashi R., Namba M.

Tissue Cult. Res. Commun. 16:173-178(1997).