MKN74Homo sapiens (Human)Cancer cell line

Also known as: MKN 74, MKN-74

🤖 AI SummaryBased on 16 publications

Quick Overview

Gastric cancer cell line with p53 wild-type and potential for drug sensitivity studies.

Detailed Summary

MKN74 is a gastric cancer cell line derived from a moderately differentiated tubular adenocarcinoma. It is characterized by wild-type p53, which suggests it may be useful for studying the role of p53 in gastric cancer. The cell line is part of a panel used in studies related to chemosensitivity and molecular characteristics of gastric cancers. Research has indicated that MKN74 exhibits specific genetic and epigenetic alterations, including potential implications for drug response and therapeutic strategies. Its use in studies involving the identification of tumor suppressor genes and oncogenes highlights its importance in understanding gastric cancer biology.

Research Applications

Chemosensitivity profilingMolecular characterization of gastric cancersDrug response studiesTumor suppressor gene analysis

Key Characteristics

Wild-type p53Moderately differentiated tubular adenocarcinoma originPart of a panel for genomic and transcriptomic studies
Generated on 6/19/2025

Basic Information

Database IDCVCL_2791
SpeciesHomo sapiens (Human)
Tissue SourceLiver[UBERON:UBERON_0002107]

Donor Information

Age37
Age CategoryAdult
SexMale
Raceasian

Disease Information

DiseaseGastric tubular adenocarcinoma
LineageEsophagus/Stomach
SubtypeTubular Stomach Adenocarcinoma
OncoTree CodeTSTAD

DepMap Information

Source TypeHSRRB
Source IDACH-000758_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Ile251Leu (c.751A>C)Unspecified-PubMed=22490663

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12
D12S391
18,21
D13S317
11
D16S539
9,11
D18S51
12
D19S433
13,15.2
D21S11
32.2,33.2
D2S1338
18,23
D3S1358
16
D5S818
11
D6S1043
13
D7S820
9
D8S1179
11,16
FGA
23
Penta D
9
Penta E
11,14
TH01
6
TPOX
8,11
vWA
16,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Int. J. Cancer 143:151-159(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

Yang H.H., Lee M.A.

PLoS ONE 9:E111146-E111146(2014).

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

A compensatory role of NF-kappaB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.

Sato K., Iwaya T., Koeda K., Wakabayashi G.

PLoS ONE 9:E90155-E90155(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.

Kong D.-X., Yamori T.

Bioorg. Med. Chem. 20:1947-1951(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

Tomoda H., Yamori T., Tsuruo T.

J. Natl. Cancer Inst. 97:765-777(2005).

Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.

Yamori T.

Mol. Cancer Ther. 4:399-412(2005).

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Okanoue T., Inazawa J.

Cancer Sci. 96:100-110(2005).

Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1.

Nakabayashi H., Kawaguchi M., Asai K., Kato T., Itoh M.

Oncogene 20:869-873(2001).

Molecular characteristics of eight gastric cancer cell lines established in Japan.

Yokozaki H.

Pathol. Int. 50:767-777(2000).

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines.

Naito S., Inoue S., Kinjo M., Tanaka K.

Gann 74:240-247(1983).

Comparison of seven cell lines derived from human gastric carcinomas.

Motoyama T., Hojo H., Watanabe H.

Acta Pathol. Jpn. 36:65-83(1986).

p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

Nakatani K., Nakano H., Sugimura T., Terada M.

Cancer Res. 51:5800-5805(1991).

Missense mutations and a deletion of the p53 gene in human gastric cancer.

Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.

Biochem. Biophys. Res. Commun. 182:215-223(1992).

Gastric tumor cell lines.";

Sekiguchi M., Suzuki T.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).

Web Resources