KNS-60Homo sapiens (Human)Cancer cell line
Also known as: KNS60, KNS 60
🤖 AI SummaryBased on 5 publications
Quick Overview
Human glioblastoma cell line with known genetic alterations.
Detailed Summary
KNS-60 is a human glioblastoma cell line derived from a brain tumor. It is commonly used in cancer research to study the molecular mechanisms of glioblastoma and to test potential therapeutic strategies. The cell line has been characterized for its genetic profile, including specific mutations and gene expression patterns that are relevant to glioblastoma biology. Research on KNS-60 has contributed to understanding the role of genetic alterations in tumor progression and drug resistance. This cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies related to drug sensitivity and resistance, as well as in the identification of potential biomarkers for cancer treatment.
Research Applications
Cancer researchDrug sensitivity and resistance studiesBiomarker identification
Key Characteristics
Genetic alterations associated with glioblastomaUsed in the Cancer Cell Line Encyclopedia (CCLE)Relevant for studying tumor progression and therapeutic strategies
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2798 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain[UBERON:UBERON_0000955] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Glioblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Glioblastoma |
| OncoTree Code | GB |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000445_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.His193Tyr (c.577C>T) | Homozygous | - | PubMed=28736828 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
8
D16S539
10,11
D18S51
15
D19S433
13
D21S11
29
D2S1338
25
D3S1358
16,18
D5S818
11
D7S820
9
D8S1179
14
FGA
18
Penta D
9,10
Penta E
8
TH01
7
TPOX
9
vWA
15,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).