JHH-7Homo sapiens (Human)Cancer cell line
Also known as: Functional Liver Cell-7, FLC7, FLC-7, JHH7, Jhh-7
Quick Overview
Human hepatocellular carcinoma cell line with metastatic potential.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_2805 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 53 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Adult hepatocellular carcinoma |
|---|---|
| Lineage | Liver |
| Subtype | Hepatocellular Carcinoma |
| OncoTree Code | HCC |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000848_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg267Pro (c.800G>C) | Unspecified | - | PubMed=24662767 |
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
A pharmacogenomic landscape in human liver cancers.";
Hui L.-J.
Cancer Cell 36:179-193.e11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Gastroenterology 157:760-776(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
Satoh M., Shimizu N., Kohara A.
R. Soc. Open Sci. 5:172472-172472(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Xu J.-C.
Hepatology 58:706-717(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A comprehensive gene expression analysis of human hepatocellular carcinoma cell lines as components of a bioartificial liver using a radial flow bioreactor.
Kosuge M., Takizawa H., Maehashi H., Matsuura T., Matsufuji S.
Liver Int. 27:101-108(2007).
Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase.
Nagamori S., Yamada Y., Saiki I.
Neoplasia 1:424-430(1999).
Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.
Gao C., Ohashi R., Pu H., Inoue Y., Tsuji T., Miyazaki M., Namba M.
Oncol. Rep. 6:1267-1271(1999).
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Fukaya K.-i., Ishioka C., Namba M.
Acta Med. Okayama 51:261-265(1997).
Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.
Kosaka T., Tsuji T., Namba M.
J. Med. Virol. 48:133-140(1996).
Establishment and characterization of a human hepatocellular carcinoma cell line JHH-7 producing alpha -fetoprotein and carcinoembryonic antigen -- changes in secretion of AFP and CEA from JHH-7 cells after heat treatment.
Shimizu K., Niiya M., Kameda H.
Hum. Cell 3:152-157(1990).
Integration of hepatitis B virus DNA into cells of six established human hepatocellular carcinoma cell lines.
Shimizu K., Niiya M., Kameda H., Fujita K., Ohno T.
Hepato-Gastroenterol. 37:457-460(1990).