HSC-1Homo sapiens (Human)Cancer cell line
Also known as: HSC-I, HSC1
🤖 AI SummaryBased on 1 publications
Quick Overview
Human skin squamous cell carcinoma cell line established in 1978.
Detailed Summary
The HSC-1 cell line was established from a human skin squamous cell carcinoma in 1978 and has been maintained in continuous culture for over 2 years. The cells exhibit epithelioid morphology with anaplastic features and show hypotetraploidy with a modal chromosome number of 80. HSC-1 cells can be cultured in vitro with 3T3 feeder layers and have been successfully cryopreserved, maintaining viability after thawing. The cell line has been used for chromosome analysis and studies on tumour characteristics, showing consistent chromosomal patterns across different passages. Additionally, HSC-1 has been transplanted into nude mice, demonstrating tumorigenic potential. The cell line provides a valuable resource for research on skin squamous cell carcinoma biology and therapeutic development.
Research Applications
chromosome analysistumour biologycancer research
Key Characteristics
hypotetraploidymodal chromosome number 80epithelioid morphologyanaplastic featurescryopreservation viabilitytumorigenic potential in nude mice
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2807 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Hand, skin[UBERON:UBERON_0001519] |
Donor Information
| Age | 75 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Skin squamous cell carcinoma |
|---|---|
| Lineage | Skin |
| Subtype | Cutaneous Squamous Cell Carcinoma |
| OncoTree Code | CSCC |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001523_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Val173Leu (c.517G>T) | Unspecified | - | PubMed=25275298 |
| MutationSimple | TP53 | p.Cys135Phe (c.404G>T) | Heterozygous | - | PubMed=22170099, PubMed=19147553, PubMed=16142320 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12,13
D13S317
11,12
D16S539
11,12
D18S51
21
D19S433
12.2,13
D21S11
30
D2S1338
19
D3S1358
16
D5S818
10,13
D7S820
11,12
D8S1179
12,14
FGA
20
Penta D
9
Penta E
5,17
TH01
7
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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