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YMB-1Homo sapiens (Human)Cancer cell line

Also known as: YMB1

🤖 AI SummaryBased on 8 publications

Quick Overview

Human breast cancer cell line with potential for research in cancer biology and drug development.

Detailed Summary

The YMB-1 cell line is a human breast cancer cell line derived from a primary tumor. It is used in cancer research to study tumor biology, drug sensitivity, and genetic mutations. This cell line has been characterized in various studies, including those focusing on gene expression, chromosomal abnormalities, and response to therapeutic agents. Research on YMB-1 contributes to understanding the molecular mechanisms of breast cancer and identifying potential targets for treatment.

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2814
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Disease Information

Disease	Invasive breast carcinoma of no special type

DepMap Information

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationNone reported	TP53	-	-	-	PubMed=19787792
MutationSimple	PTEN	p.Leu108Arg (c.323T>G)	Homozygous	-	from parent cell line ZR-75-1
MutationSimple	HRAS	p.Glu162Lys (c.484G>A)	Homozygous	-	from parent cell line ZR-75-1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,11

D13S317

9

D16S539

11

D5S818

13

D7S820

10,11

TH01

7,9.3

TPOX

8

vWA

16,18

Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Match criteria for human cell line authentication: where do we draw the line?

Masters J.R.W., Kerrigan L.

Int. J. Cancer 132:2510-2519(2013).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

Tomoda H., Yamori T., Tsuruo T.

J. Natl. Cancer Inst. 97:765-777(2005).

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

Establishment and characterization of new cell line (YMB-1) derived from human breast carcinoma.

Okumichi T., Naito M., Ito A., Ezaki H.

Hiroshima J. Med. Sci. 33:715-720(1984).

Cell lines from human breast.";

Leibovitz A.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York; USA (1994).

Web Resources