YMB-1-EHomo sapiens (Human)Cancer cell line
Also known as: YMB1E, YMB1-E
🤖 AI SummaryBased on 4 publications
Quick Overview
Human cancer cell line for research on oncogenic fusions and drug response.
Detailed Summary
YMB-1-E is a human cancer cell line derived from an unspecified tissue and disease. It is used in research to study oncogenic fusions, gene expression, and drug response. The cell line has been analyzed for its transcriptomic and genomic features, including mutations, gene fusions, and viral sequences. It is part of large-scale studies to understand cancer biology and develop targeted therapies. Research on YMB-1-E contributes to the identification of biomarkers for drug sensitivity and resistance.
Research Applications
Oncogenic fusion detectionDrug response profilingTranscriptomic analysisGenomic mutation studies
Key Characteristics
Expression of viral sequencesPresence of gene fusionsTranscriptome data availability
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2815 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Disease Information
| Disease | Invasive breast carcinoma of no special type |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | PTEN | p.Leu108Arg (c.323T>G) | Homozygous | - | from parent cell line ZR-75-1 |
| MutationSimple | KRAS | p.Lys117Asn (c.351A>T) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | HRAS | p.Glu162Lys (c.484G>A) | Homozygous | - | from parent cell line ZR-75-1 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
9
D16S539
11
D5S818
13
D7S820
10,11
TH01
7,9.3
TPOX
8
vWA
16,18
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Match criteria for human cell line authentication: where do we draw the line?
Masters J.R.W., Kerrigan L.
Int. J. Cancer 132:2510-2519(2013).