DL-40Homo sapiens (Human)Cancer cell line
Also known as: DL40
🤖 AI SummaryBased on 4 publications
Quick Overview
T-cell lymphoma cell line for cancer research
Detailed Summary
DL-40 is a T-cell lymphoma cell line derived from an aggressive large cell lymphoma. It is characterized by a mutation in the p53 gene, specifically a T to G transition in exon 5, leading to a Cys to Phe change at codon 176. This cell line exhibits resistance to ionizing radiation-induced apoptosis, with delayed apoptotic responses compared to cell lines with wild-type p53. DL-40 has been used in studies investigating the mechanisms of radiation resistance and the role of p53 in apoptosis. Additionally, DL-40 has been utilized in research on cytokine receptor signaling and JAK/STAT pathway dependencies in anaplastic large cell lymphoma (ALCL).
Research Applications
Cancer researchApoptosis mechanismsRadiation resistanceJAK/STAT pathway studies
Key Characteristics
p53 mutation (T to G in exon 5)Resistance to ionizing radiation-induced apoptosisCytokine receptor signaling dependency
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2889 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 64 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | ALK-negative anaplastic large cell lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Anaplastic Large-Cell Lymphoma ALK Negative |
| OncoTree Code | ALCLALKN |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001060_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys176Phe (c.527G>T) | Unspecified | - | PubMed=8221663 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
13,14
D13S317
9,13
D16S539
10,11
D5S818
9,12
D7S820
10,11
TH01
8
TPOX
8,9
vWA
14,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Kadin M.E., Del Mistro A., Woessner R.D., Jaffe E.S., Waldmann T.A.
Proc. Natl. Acad. Sci. U.S.A. 114:3975-3980(2017).
Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma.
Drexler H.G., MacLeod R.A.F.
Leukemia 18:1569-1571(2004).
Ionizing radiation-induced apoptosis in human lymphoma cell lines differing in p53 status.
Kariya S., Terashima M., Kubonishi I., Yoshida S.
Int. J. Mol. Med. 5:139-143(2000).
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Liu C., Kondo E., Minowada J., Akagi T.
Jpn. J. Cancer Res. 87:1070-1077(1996).
A Ki-1 (CD30)-positive T (E+, CD4+, Ia+)-cell line, DL-40, established from aggressive large cell lymphoma.
Ohyashiki K., Toyama K., Ohtsuki Y., Miyoshi I.
Cancer Res. 50:7682-7685(1990).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).